Evaluation of the preoperative neutrophil-to-lymphocyte ratio as a predictor of the micropapillary component of stage IA lung adenocarcinoma.

Cheng Chen, Zhi-jun Chen, Wu-Jun Li, Tao Deng, Han-Bo Le, Yong-Kui Zhang, Bin-Jie Zhang
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Abstract

OBJECTIVE To assess the ability of markers of inflammation to identify the solid or micropapillary components of stage IA lung adenocarcinoma and their effects on prognosis. METHODS We performed a retrospective study of clinicopathologic data from 654 patients with stage IA lung adenocarcinoma collected between 2013 and 2019. Logistic regression analysis was used to identify independent predictors of these components, and we also evaluated the relationship between markers of inflammation and recurrence. RESULTS Micropapillary-positive participants had high preoperative neutrophil-to-lymphocyte ratios. There were no significant differences in the levels of markers of systemic inflammation between the participants with or without a solid component. Multivariate analysis showed that preoperative neutrophil-to-lymphocyte ratio (odds ratio [OR] = 2.094; 95% confidence interval [CI], 1.668-2.628), tumor size (OR = 1.386; 95% CI, 1.044-1.842), and carcinoembryonic antigen concentration (OR = 1.067; 95% CI, 1.017-1.119) were independent predictors of a micropapillary component. There were no significant correlations between markers of systemic inflammation and the recurrence of stage IA lung adenocarcinoma. CONCLUSIONS Preoperative neutrophil-to-lymphocyte ratio independently predicts a micropapillary component of stage IA lung adenocarcinoma. Therefore, the potential use of preoperative neutrophil-to-lymphocyte ratio in the optimization of surgical strategies for the treatment of stage IA lung adenocarcinoma should be further studied.
评估术前中性粒细胞与淋巴细胞比值作为肺腺癌IA期微乳头状组成部分的预测指标。
目的评估炎症标志物识别IA期肺腺癌实体或微乳头状成分的能力及其对预后的影响。方法我们对2013年至2019年间收集的654名IA期肺腺癌患者的临床病理数据进行了回顾性研究。结果微乳头状瘤阳性患者术前中性粒细胞与淋巴细胞比率较高。有无实性成分的参与者在全身炎症标志物水平上没有明显差异。多变量分析显示,术前中性粒细胞与淋巴细胞比值(比值比 [OR] = 2.094;95% 置信区间 [CI],1.668-2.628)、肿瘤大小(比值比 [OR] = 1.386;95% 置信区间 [CI],1.044-1.842)和癌胚抗原浓度(比值比 [OR] = 1.067;95% 置信区间 [CI],1.017-1.119)是微乳头状成分的独立预测因子。结论术前中性粒细胞与淋巴细胞比值可独立预测IA期肺腺癌的微乳头状成分。因此,应进一步研究术前中性粒细胞与淋巴细胞比值在优化治疗IA期肺腺癌手术策略中的潜在用途。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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