Improvement of Solubility Usnic Acid Loaded on Mesoporous Silica SBA-15 and Physicochemical Characterization

Q2 Pharmacology, Toxicology and Pharmaceutics

Science and Technology Indonesia Pub Date : 2024-04-02 DOI:10.26554/sti.2024.9.2.251-259

L. Fitriani, Cindy Maynia Azzahra, Adhitya Jessica, Uswatul Hasanah, Erizal Zaini

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Abstract

Usnic acid, a secondary metabolite of lichen Usnea sp., has several pharmacological activities, but it is poorly soluble in water. This study aimed to improve the solubility and dissolution rate of usnic acid loaded in mesoporous silica SBA-15 at a mass ratio of 1:1. and evaluate its physical stability. Physicochemical characterization was carried out via the nitrogen adsorption desorption isotherm, differential scanning calorimetry (DSC), Fourier transform infrared (FTIR) spectroscopy, and powder X-ray diffraction (PXRD). Usnic acid-loaded SBA-15 was stored at 40 °C with various relative humidities (RH) and then analyzed by PXRD for the physical stability. Usnic acid adsorbed well in the pores of SBA-15, as shown by a decrease in the volume pore and surface area of SBA-15 according to the nitrogen adsorption. Moreover, usnic acid-SBA-15 showed a decrease in the degree of crystallinity according to PXRD analysis and no melting point based on DSC analysis. The FTIR spectrum of usnic acid–SBA-15 corresponds to the spectra of each raw material. The solubility of usnic acid increased 5.15 times after adsorbed on SBA-15. The dissolution rate also showed a significant increase (p < 0.05) from 19.51% to 84.27%. Usnic acid–SBA-15 was relatively stable at RH 75%. Thus, the adsorption of usnic acid on SBA-15 can increase its solubility, dissolution rate, and physical stability.

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介孔二氧化硅 SBA-15 上负载的松萝酸溶解度的改善及理化特性分析

Usnic acid 是地衣Usnea sp.的次级代谢产物，具有多种药理活性，但在水中的溶解度很低。本研究旨在以 1:1 的质量比改善介孔二氧化硅 SBA-15 中负载的乌司尼酸的溶解度和溶解速率，并评估其物理稳定性。本研究通过氮吸附解吸等温线、差示扫描量热法（DSC）、傅立叶变换红外光谱（FTIR）和粉末 X 射线衍射（PXRD）进行了理化表征。在不同相对湿度（RH）条件下，将含有烟酸的 SBA-15 储存在 40 °C，然后用 PXRD 分析其物理稳定性。根据氮的吸附情况，SBA-15 的孔隙体积和表面积都有所减小，这表明烟酸能很好地吸附在 SBA-15 的孔隙中。此外，根据 PXRD 分析，丁二酸-SBA-15 的结晶度降低，而根据 DSC 分析，丁二酸-SBA-15 没有熔点。usnic acid-SBA-15 的傅立叶变换红外光谱与每种原材料的光谱一致。吸附到 SBA-15 上后，烟酸的溶解度增加了 5.15 倍。溶解率也从 19.51% 显著提高到 84.27%（p < 0.05）。在相对湿度为 75% 时，松萝酸-SBA-15 相对稳定。因此，在 SBA-15 上吸附烟酸可以增加其溶解度、溶解速率和物理稳定性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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