Impaired kidney function among young healthcare workers with long working hours and night work.

IF 5.4 3区材料科学 Q2 CHEMISTRY, PHYSICAL

ACS Applied Energy Materials Pub Date : 2024-04-03 DOI:10.5271/sjweh.4159

W. Chen, H. Yang

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引用次数: 0

Abstract

OBJECTIVES We aimed to evaluate the association between long working hours, night work, and estimated glomerular filtration rate (eGFR) among young healthcare workers. METHODS We conducted a retrospective cohort study among healthcare workers in a tertiary medical center in Taiwan from 2002 to 2021. Other than physicians, all hospital employees aged 20-65 years with documented yearly working hours and an annual blood test including creatinine were eligible. We excluded participants with eGFR <60 ml/min/1.73 m2 and proteinuria at enrollment to focus on early renal impairment. Total working hours, night working hours, and eGFR in each year were collected. We assessed the relationship of total working hours and night and non-night working hours with eGFR using the generalized linear mixed model, adjusting for demographic, comorbidities, and laboratory profiles. RESULTS The study included 10 677 participants with a mean age of 27.2 (standard deviation 7.1) years. The mean follow-up duration was 6.2 years. For every 10-hour increase in total weekly working hours, the eGFR decreased by 0.86 [95% confidence interval (CI) 0.61-1.11] ml/min/1.73 m2. For every 10-hour increase in weekly night working hours, the eGFR decreased by 0.25 (95% CI 0.07-0.42) ml/min/1.73 m2. In stratified analysis, the negative associations between total working hours and eGFR remained in the subgroups of individuals aged <40 years and those without hypertension or diabetes, with a P-value for interaction of <0.05. CONCLUSIONS Longer working hours and night work were associated with lower eGFR among healthcare workers.

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长时间和夜间工作的年轻医护人员肾功能受损。

目的：我们旨在评估年轻医护人员长时间工作、夜间工作与估计肾小球滤过率（eGFR）之间的关系。方法：我们对台湾一家三级医疗中心的医护人员进行了一项回顾性队列研究（2002-2021 年）。除医生外，所有年龄在 20-65 岁之间、有年度工作时间记录和年度血液检查（包括肌酐）的医院员工均符合条件。我们排除了 eGFR <60 ml/min/1.73 m2 和蛋白尿的参与者，以关注早期肾功能损害。我们收集了每年的总工作时间、夜间工作时间和 eGFR。我们使用广义线性混合模型评估了总工作时间、夜间和非夜间工作时间与 eGFR 的关系，并对人口统计学、合并症和实验室资料进行了调整。平均随访时间为 6.2 年。每周总工时每增加 10 小时，eGFR 就会下降 0.86 [95% 置信区间（CI）0.61-1.11] ml/min/1.73 m2。每周夜间工作时间每增加 10 小时，eGFR 就会下降 0.25（95% 置信区间为 0.07-0.42）毫升/分钟/1.73 平方米。在分层分析中，总工时与 eGFR 之间的负相关在年龄小于 40 岁和无高血压或糖尿病的亚组中依然存在，交互作用的 P 值小于 0.05。

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来源期刊

ACS Applied Energy Materials Materials Science-Materials Chemistry

CiteScore

10.30

自引率

6.20%

发文量

1368

期刊介绍： ACS Applied Energy Materials is an interdisciplinary journal publishing original research covering all aspects of materials, engineering, chemistry, physics and biology relevant to energy conversion and storage. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important energy applications.