Effect of Bitter Melon's Extract Fraction (Momordica Charantia L.) on Blood Sugar Reduction, Insulin Resistance and Phosphatidyl Inositol 3-Kinase (PI3K) Signalling in Male Rats (Rattus novergicus) Streptozotocin-Induced Hyperglycemia

Jurnal sosial dan sains Pub Date : 2024-04-03 DOI:10.59188/jurnalsosains.v4i3.1256

Gustiany Nadya Damanik

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Abstract

Background: Diabetes mellitus (DM) is a metabolic disease characterized by symptoms of hyperglycemia as a result of impaired insulin secretion. The main cause of type 2 diabetes mellitus is metabolic disorders characterized by insulin receptor resistance, reduced ability of β-pancreatic cells to secrete insulin, and abnormalities in insulin secretion from pancreatic β islet of Langerhans cells. In insulin resistance, the presence of impaired signaling in Phosphatidylinositol 3-kinase (PI3K) disrupts glucose regulation in the body. The purpose of this study was to determine the effect of bitter melon extract (Momordica charantia L.) on blood sugar reduction, insulin resistance and phosphatidyl inositol 3-kinase (PI3K) signaling. Purpose : The objectives of this study are Effect of Bitter Melon's Extract Fraction (Momordica Charantia L.) on Blood Sugar Reduction, Insulin Resistance and Phosphatidyl Inositol 3-Kinase (PI3K) Signalling in Male Rats (Rattus novergicus) Streptozotocin-Induced Hyperglycemia Method: This study used a type of laboratory experimental research post-test randomized controlled group design on hyperglycemic male rats (Rattus novergicus). All data analysis is done using SPSS software. Results: Based on research conducted, it is known that bitter melon extract affects blood sugar, insulin resistance and PI3K signaling. Conclusion: Bitter melon extract has potential as an herbal antidiabetic remedy

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苦瓜提取物对链脲佐菌素诱导的高血糖雄性大鼠血糖降低、胰岛素抵抗和磷脂酰肌醇 3-Kinase (PI3K) 信号传导的影响

背景：糖尿病（DM）是一种以胰岛素分泌受损导致高血糖症状为特征的代谢性疾病。2 型糖尿病的主要病因是以胰岛素受体抵抗、β-胰腺细胞分泌胰岛素的能力下降以及胰腺β-朗格汉斯胰岛细胞分泌胰岛素异常为特征的代谢紊乱。在胰岛素抵抗中，磷脂酰肌醇 3- 激酶（PI3K）的信号传导功能受损，从而破坏了体内的葡萄糖调节功能。本研究旨在确定苦瓜提取物（Momordica charantia L.）对降低血糖、胰岛素抵抗和磷脂酰肌醇 3- 激酶（PI3K）信号传导的影响。目的：本研究的目的是苦瓜提取物对雄性大鼠（Rattus novergicus）链脲佐菌素诱导的高血糖症中血糖降低、胰岛素抵抗和磷脂酰肌醇 3-激酶（PI3K）信号传导的影响：本研究以高血糖雄性大鼠（Rattus novergicus）为对象，采用实验室实验研究后测随机对照分组设计。所有数据均使用 SPSS 软件进行分析。研究结果研究表明，苦瓜提取物会影响血糖、胰岛素抵抗和 PI3K 信号传导。结论苦瓜提取物具有草药抗糖尿病疗法的潜力

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