Association of Dyslipidemia in Decreased Glomerular Filtration Rate in Patients with CKD KDIGO ≥ 3

Abstract

Objective. To determine the association of dyslipidemia with decreased glomerular filtration rate (eGFR) in patients with CKD KDIGO ≥3. Material and methods. Observational, analytical, longitudinal, ambispective study; was carried out at the Family Medicine Unit (UMF) No. 55 Zumpango, the sample size was calculated using the mean difference formula, with an expected mean of 5.2, obtaining n= 90 patients with CKD KDIGO ≥3 , between 20-69 years. Patients with dyslipidemia and without dyslipidemia were classified into 2 groups, in which creatinine was evaluated to calculate the estimated glomerular filtration rate (eGFR), total cholesterol and triglycerides, subjects with renal function replacement therapy, patients with pathologies or treatments that modify lipid metabolism. For the bivariate analysis, the Student’s T test and the Mann-Whitney U test were applied according to the type of distribution presented by the eGFR values for the groups with and without dyslipidemia. Result and conclusion. Based on the eGFR values for the groups with and without dyslipidemia, they show that patients aged 20 to 69 years with CKD KDIGO ≥ 3 with dyslipidemia presented a mean eGFR of 40.24 for the first analysis, and 34.70 for the follow-up analysis., with a mean difference of 5.53, which was significant (p=0.003).