The asbestos-asbestosis exposure-response relationship: a cohort study of the general working population.

IF 5.4 3区材料科学 Q2 CHEMISTRY, PHYSICAL

ACS Applied Energy Materials Pub Date : 2024-04-04 DOI:10.5271/sjweh.4153

I. Iversen, J. Vestergaard, J. Ohlander, Susan Peters, Elisabeth Bendstrup, J. Bonde, Vivi Schlünssen, J. Bønløkke, F. Rasmussen, Z. Stokholm, M. B. Andersen, H. Kromhout, H. Kolstad

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引用次数: 0

Abstract

OBJECTIVES The association between asbestos exposure and asbestosis in high-exposed industrial cohorts is well-known, but there is a lack of knowledge about the exposure-response relationship for asbestosis in a general working population setting. We examined the exposure-response relationship between occupational asbestos exposure and asbestosis in asbestos-exposed workers of the Danish general working population. METHODS We followed all asbestos-exposed workers from 1979 to 2015 and identified incident cases of asbestosis using the Danish National Patient Register. Individual asbestos exposure was estimated with a quantitative job exposure matrix (SYN-JEM) from 1976 onwards and back-extrapolated to age 16 for those exposed in 1976. Exposure-response relations for cumulative exposure and other exposure metrics were analyzed using a discrete time hazard model and adjusted for potential confounders. RESULTS The range of cumulative exposure in the population was 0.001 to 18 fibers per milliliter-year (f/ml-year). We found increasing incidence rate ratios (IRR) of asbestosis with increasing cumulative asbestos exposure with a fully adjusted IRR per 1 f/ml-years of 1.18 [95% confidence interval (CI) 1.15- -1.22]. The IRR was 1.94 (95% CI 1.53-2.47) in the highest compared to the lowest exposure tertile. We similarly observed increasing risk with increasing cumulative exposure in the inception population. CONCLUSIONS This study found exposure-response relations between cumulative asbestos exposure and incident asbestosis in the Danish general working population with mainly low-level exposed occupations, but there is some uncertainty regarding the exposure levels.

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石棉--石棉沉滞症暴露--反应关系：对普通劳动人口的队列研究。

目的众所周知，在高暴露的工业人群中，石棉暴露与石棉沉滞症之间存在关联，但对于普通劳动人群中石棉沉滞症的暴露-反应关系却缺乏了解。我们研究了丹麦普通劳动人口中暴露于石棉的工人的职业石棉暴露与石棉沉滞症之间的暴露-反应关系。方法我们从 1979 年到 2015 年对所有暴露于石棉的工人进行了跟踪调查，并通过丹麦全国患者登记册确定了石棉沉滞症的偶发病例。我们使用定量工作暴露矩阵（SYN-JEM）估算了自 1976 年以来的个人石棉暴露量，并将 1976 年暴露于石棉的工人的年龄反推至 16 岁。采用离散时间危害模型分析了累积暴露和其他暴露指标的暴露-反应关系，并对潜在的混杂因素进行了调整。结果人群的累积暴露范围为 0.001 至 18 纤维/毫升-年（f/ml-年）。我们发现石棉沉滞症的发病率比（IRR）随累积石棉暴露量的增加而增加，每 1 纤维/毫升-年的完全调整 IRR 为 1.18 [95% 置信区间 (CI) 1.15--1.22]。与最低暴露三分位数相比，最高暴露三分位数的 IRR 为 1.94（95% 置信区间为 1.53-2.47）。结论：本研究发现，在主要从事低水平暴露职业的丹麦普通劳动人口中，累积石棉暴露与石棉沉滞症发病之间存在暴露-反应关系，但暴露水平存在一定的不确定性。

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来源期刊

ACS Applied Energy Materials Materials Science-Materials Chemistry

CiteScore

10.30

自引率

6.20%

发文量

1368

期刊介绍： ACS Applied Energy Materials is an interdisciplinary journal publishing original research covering all aspects of materials, engineering, chemistry, physics and biology relevant to energy conversion and storage. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important energy applications.