Gangliosides as Therapeutic Targets for Neurodegenerative Diseases

IF 5.9 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
O. K. Inci, Hande Basırlı, Melike Can, Selman Yanbul, V. Seyrantepe
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引用次数: 0

Abstract

Gangliosides, sialic acid-containing glycosphingolipids, are abundant in cell membranes and primarily involved in controlling cell signaling and cell communication. The altered ganglioside pattern has been demonstrated in several neurodegenerative diseases, characterized during early-onset or infancy, emphasizing the significance of gangliosides in the brain. Enzymes required for the biosynthesis of gangliosides are linked to several devastating neurological disorders, including Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), amyotrophic lateral sclerosis (ALS), hereditary spastic paraplegia (HSP). In this review, we summarized not only the critical roles of biosynthetic enzymes and their inhibitors in ganglioside metabolism but also the efficacy of treatment strategies of ganglioside to address their significance in those diseases.
神经节苷脂作为神经退行性疾病的治疗靶点
神经节苷脂是一种含硅醛酸的糖磷脂,在细胞膜中含量丰富,主要参与控制细胞信号传导和细胞通讯。神经节苷脂模式的改变已在几种神经退行性疾病中得到证实,这些疾病的特点是发病初期或婴儿期,这强调了神经节苷脂在大脑中的重要性。神经节苷脂生物合成所需的酶与几种破坏性神经系统疾病有关,包括阿尔茨海默病(AD)、帕金森病(PD)、亨廷顿病(HD)、肌萎缩性脊髓侧索硬化症(ALS)和遗传性痉挛性截瘫(HSP)。在这篇综述中,我们不仅总结了生物合成酶及其抑制剂在神经节苷脂代谢中的关键作用,还总结了神经节苷脂治疗策略的疗效,以探讨它们在这些疾病中的意义。
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来源期刊
Journal of Lipids
Journal of Lipids BIOCHEMISTRY & MOLECULAR BIOLOGY-
自引率
0.00%
发文量
7
审稿时长
12 weeks
期刊介绍: Journal of Lipids is a peer-reviewed, Open Access journal that publishes original research articles and review articles related to all aspects of lipids, including their biochemistry, synthesis, function in health and disease, and nutrition. As an interdisciplinary journal, Journal of Lipids aims to provide a forum for scientists, physicians, nutritionists, and other relevant health professionals.
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