Coupling between Regional Oxygen Saturation of the Brain and Vital Signs during Immediate Transition after Birth.

Neonatology Pub Date : 2024-04-08 DOI:10.1159/000534524
Dries Hendrikx, Alexander Caicedo Dorado, Sabine Van Huffel, Gunnar Naulaers, C. Wolfsberger, B. Urlesberger, G. Pichler
{"title":"Coupling between Regional Oxygen Saturation of the Brain and Vital Signs during Immediate Transition after Birth.","authors":"Dries Hendrikx, Alexander Caicedo Dorado, Sabine Van Huffel, Gunnar Naulaers, C. Wolfsberger, B. Urlesberger, G. Pichler","doi":"10.1159/000534524","DOIUrl":null,"url":null,"abstract":"INTRODUCTION\nThe primary aim was to analyze any coupling of heart rate (HR)/arterial oxygen saturation (SpO2) and regional cerebral oxygen saturation (rScO2) and regional cerebral fractional tissue oxygen extraction (cFTOE) during immediate transition after birth in term and preterm neonates to gain more insight into interactions.\n\n\nMETHODS\nThe present study is a post hoc analysis of data from 106 neonates, obtained from a prospective, observational study. Measurements of HR, SpO2, rScO2, and cFTOE were performed during the first 15 min after birth. The linear and nonlinear correlation were computed between these parameters in a sliding window. The resulting coupling curves were clustered. After clustering, demographic data of the clusters were de-blinded and compared.\n\n\nRESULTS\nDue to missing data, 58 out of 106 eligible patients were excluded. Two clusters were obtained: cluster 1 (N = 39) and cluster 2 (N = 9). SpO2 had linear and nonlinear correlations with rScO2 and cFTOE, whereby the correlations with rScO2 were more pronounced in cluster 2. HR-rScO2 and HR-cFTOE demonstrated a nonlinear correlation in both clusters, again being more pronounced in cluster 2, whereby linear correlations were mainly absent. After de-blinding, the demographic data revealed that the neonates in cluster 2 had significantly lower gestational age (mainly preterm) compared to cluster 1 (mainly term).\n\n\nDISCUSSION\nBesides SpO2, also HR demonstrated a nonlinear correlation with rScO2 and cFTOE in term and preterm neonates during immediate transition after birth. In addition, the coupling of SpO2 and HR with cerebral oxygenation was more pronounced in neonates with a lower gestational age.","PeriodicalId":94152,"journal":{"name":"Neonatology","volume":"16 9","pages":"1-10"},"PeriodicalIF":0.0000,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neonatology","FirstCategoryId":"0","ListUrlMain":"https://doi.org/10.1159/000534524","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

INTRODUCTION The primary aim was to analyze any coupling of heart rate (HR)/arterial oxygen saturation (SpO2) and regional cerebral oxygen saturation (rScO2) and regional cerebral fractional tissue oxygen extraction (cFTOE) during immediate transition after birth in term and preterm neonates to gain more insight into interactions. METHODS The present study is a post hoc analysis of data from 106 neonates, obtained from a prospective, observational study. Measurements of HR, SpO2, rScO2, and cFTOE were performed during the first 15 min after birth. The linear and nonlinear correlation were computed between these parameters in a sliding window. The resulting coupling curves were clustered. After clustering, demographic data of the clusters were de-blinded and compared. RESULTS Due to missing data, 58 out of 106 eligible patients were excluded. Two clusters were obtained: cluster 1 (N = 39) and cluster 2 (N = 9). SpO2 had linear and nonlinear correlations with rScO2 and cFTOE, whereby the correlations with rScO2 were more pronounced in cluster 2. HR-rScO2 and HR-cFTOE demonstrated a nonlinear correlation in both clusters, again being more pronounced in cluster 2, whereby linear correlations were mainly absent. After de-blinding, the demographic data revealed that the neonates in cluster 2 had significantly lower gestational age (mainly preterm) compared to cluster 1 (mainly term). DISCUSSION Besides SpO2, also HR demonstrated a nonlinear correlation with rScO2 and cFTOE in term and preterm neonates during immediate transition after birth. In addition, the coupling of SpO2 and HR with cerebral oxygenation was more pronounced in neonates with a lower gestational age.
出生后即刻过渡期间大脑区域氧饱和度与生命体征之间的耦合。
简介:本研究的主要目的是分析足月儿和早产儿出生后立即过渡期间心率(HR)/动脉血氧饱和度(SpO2)与区域脑氧饱和度(rScO2)和区域脑组织氧萃取分数(cFTOE)之间的任何耦合关系,以深入了解其相互作用。在新生儿出生后 15 分钟内测量了 HR、SpO2、rScO2 和 cFTOE。在滑动窗口中计算了这些参数之间的线性和非线性相关性。由此得出的耦合曲线被聚类。结果由于数据缺失,106 名符合条件的患者中有 58 人被排除在外。得出两个聚类:聚类 1(39 人)和聚类 2(9 人)。SpO2 与 rScO2 和 cFTOE 存在线性和非线性相关性,其中第 2 组与 rScO2 的相关性更为明显。HR-rScO2 和 HR-cFTOE 在两个群组中都显示出非线性相关性,同样在群组 2 中更为明显,而在群组 2 中主要没有线性相关。去盲后,人口统计学数据显示,与第 1 组(主要是足月儿)相比,第 2 组新生儿的胎龄明显较低(主要是早产儿)。此外,胎龄越小的新生儿 SpO2 和 HR 与脑氧合的耦合关系越明显。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信