Intelligent Differentiation Framework for Lewy Body Dementia and Alzheimer’s disease using Adaptive Multi-Cascaded ResNet–Autoencoder–LSTM Network

Abstract

In recent years, most of the patients with dementia have acquired healthcare systems within the primary care system and they also have some challenging psychiatric and medical issues. Here, dementia-based symptoms are not identified in the primary care center, because they are affected by various factors like psychological symptoms, clinically relevant behavior, numerous psychotropic medications, and multiple chronic medical conditions. To enhance the healthcare-related applications, the primary healthcare system with additional resources like coordination with interdisciplinary dementia specialists, feasible diagnosis, and screening process need to be improved. Therefore, the differentiation between Alzheimer’s Disease (AD) and Lewy Body Dementia (LBD) has been acquired to provide the best clinical support to the patients. In this research work, the deep structure depending on AD and LBD systems has been implemented with the help of an adaptive algorithm to provide promising outcomes over dementia detection. Initially, the input images are collected from online sources. Thus, the collected images are forwarded to the newly designed Multi-Cascaded Deep Learning (MSDL), where the ResNet, Autoencoder, and weighted Long-Short Term Memory (LSTM) networks are serially cascaded to provide effective classification results. Then, the fully connected layer of ResNet is given to the Autoencoder structure. Here, the output from the encoder phase is optimized by using the Adaptive Water Wave Cuttlefish Optimization (AWWCO), which is derived from the Water Wave Optimization (WWO) and Cuttlefish Algorithm (CA), and the resultant selected output is fed to the weight-optimized LSTM network. Further, the parameters in the MSDL network are optimized by using the same AWWCO algorithm. Finally, the performance comparison over different heuristic algorithms and conventional dementia detection approaches is done for the validation of the overall effectiveness of the suggested model in terms of various estimation measures.