Research Progress in the Relationship Between P2X7 and Flavonoids in Cardiovascular Disease

Abstract

Inhibition of P2X7 receptor overexpression is essential in cardiovascular diseases (CVDs). Flavonoids can reduce the mortality of CVDs through anti-inflammatory effects, and P2X7 receptor activation can lead to inflammation. Therefore, studying the effect of flavonoids on P2X7 will help develop safe and effective target drugs for prevention and treatment of CVDs. The aim of this article is to review the literature regarding flavonoids and their various actions on P2X7. Molecular docking showed that the VINA scores of naringin, genistin, and baicalin were lower or equal to the specific inhibitor A804598, which will help in the development of novel therapeutic agents for CVDs.