Minimally Verbal Individuals with Autism Spectrum Disorders/Intellectual Disability and Challenging Behaviors: Can Strategic Psychiatric Treatment Help?

Jessica A. Hellings, Saras Chen Singh, Sham Singh, An-Lin Cheng
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Abstract

(1) Background: Psychiatrists are increasingly required to treat minimally verbal (MV) individuals with autism spectrum disorder (ASD), intellectual disability (ID) and behavior problems without much published guidance. (2) Methods: We reviewed 80 charts of MV patients managed strategically for challenging behaviors, following IRB approval. Data extracted included demographics, ASD/ID level, diagnoses, epilepsy and medications. In this descriptive study, we examined the course of assessment and treatment and made recommendations for a strategic, person-centered approach. (3) Results: Of 53 males and 27 females, mean age 34 years (range 7–76), all had ID; 75 had ASD (94%). Diagnoses included seizures in 40/80 (50%), frequent aggression (89%), self-injury (80%), attention-deficit hyperactivity disorder (ADHD) (64%) and obsessive compulsive disorder (OCD) (34%). The commonest medication classes adjusted were antiseizure medications, antipsychotics, and non-stimulant ADHD medications. (4) Conclusions: Clinical impressions suggested that this strategic psychiatric approach was beneficial, notably a review of antiseizure and all other medications for polypharmacy, behavioral and other side effects, followed by a review of possible childhood/current ADHD and a trial of low-dose non-stimulant ADHD medications if warranted. Low-dose risperidone was often effective and tolerable for irritability and self-injury.
患有自闭症谱系障碍/智力障碍和挑战行为的极少言语者:策略性精神病治疗能有所帮助吗?
(1) 背景:精神科医生越来越多地需要治疗患有自闭症谱系障碍(ASD)、智力障碍(ID)和行为问题的最小言语能力(MV)患者,但却没有很多公开发表的指导意见。(2)方法:经 IRB 批准,我们审查了 80 名因挑战行为而接受策略性管理的 MV 患者的病历。提取的数据包括人口统计学、ASD/ID 水平、诊断、癫痫和药物。在这项描述性研究中,我们检查了评估和治疗的过程,并就以人为本的战略方法提出了建议。(3) 结果:53 名男性和 27 名女性,平均年龄 34 岁(7-76 岁不等),全部患有智障;75 名患有 ASD(94%)。诊断包括 40/80 例癫痫发作(50%)、频繁攻击行为(89%)、自伤(80%)、注意力缺陷多动障碍(ADHD)(64%)和强迫症(OCD)(34%)。最常见的调整药物类别是抗癫痫药物、抗精神病药物和非刺激性多动症药物。(4) 结论:临床印象表明,这种战略性的精神治疗方法是有益的,尤其是对抗癫痫药物和所有其他药物进行复查,以确定是否存在多重用药、行为和其他副作用,然后对可能的儿童/并发多动症进行复查,并在必要时试用低剂量非刺激性多动症药物。小剂量利培酮对烦躁和自伤通常有效且可以耐受。
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