Systemic arterial hypertension and metabolic profile: a systematic review

Q2 Medicine
Gabriela B Souza, Marina Buchpiguel, Antonietta B Rossetto, Luiz A Bortolotto, Wanderley M Bernardo, Luca S Tristão, Guilherme Tavares, Edson G Lo Turco, Irineu F D S Massaia, José M. Aldrighi
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引用次数: 1

Abstract

Introduction: Systemic arterial hypertension (SAH) is a significant cause of morbidity and mortality worldwide. Despite the difficulty in diagnosing SAH in the early stages, the rapid detection and management of SAH are essential in preventing the development of target organ injuries. Newer technologies such as metabolomics have been revealed as promising alternatives for SAH diagnoses. Objectives: The purpose of this study is to evaluate, through a systematic review, the metabolomic profile of individuals with and without SAH. Methods: This review followed the PRISMA guidelines on reporting items. It analyses articles selected from the EMBASE and MEDLINE databases that compares metabolites in a hypertensive group with a non-hypertensive group. Results: The differences that reached statistical significance were a higher prevalence of lipids and lactic acid in the hypertensive group, as well as a reduction in methionine. Conclusion: Future research should be conducted to establish a possible clinical implication to this metabolite alteration, by linking it to a potential target organ injury for SAH, such as atherosclerosis, renal failure, retinopathy our ventricular hypertrophy.
全身动脉高血压与代谢概况:系统综述
导言:全身性动脉高血压(SAH)是全球发病率和死亡率的重要原因。尽管很难在早期诊断出 SAH,但快速检测和处理 SAH 对预防靶器官损伤的发展至关重要。代谢组学等新技术被认为是诊断 SAH 的有前途的替代方法:本研究的目的是通过系统综述评估 SAH 患者和非 SAH 患者的代谢组学特征:本综述遵循 PRISMA 报告项目指南。研究分析了从 EMBASE 和 MEDLINE 数据库中选取的文章,这些文章对高血压组和非高血压组的代谢物进行了比较:结果:高血压组的脂质和乳酸含量较高,蛋氨酸含量较低,这些差异具有统计学意义:今后的研究应通过将代谢物的变化与 SAH 的潜在靶器官损伤(如动脉粥样硬化、肾功能衰竭、视网膜病变和心室肥大)联系起来,以确定其可能的临床意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Human Growth and Development
Journal of Human Growth and Development Social Sciences-Life-span and Life-course Studies
CiteScore
2.70
自引率
0.00%
发文量
37
审稿时长
22 weeks
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