The Role of Lactobacillus Reuteri Probiotic for Preventing Functional Gastrointestinal Disorders in Toddlerhood

Mohammad Uddin, Shahab Uddin, Bishwajit Deb, Tania Hussain, Sohel Rafi, Azizul Islam
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Abstract

Probiotic Lactobacillus reuteri has been shown to be useful for a number of gastrointestinal disorders. Its ability to secrete antimicrobial compounds, prevent pathogenic microorganisms from colonizing the host, and alter the composition of the commensal microbiota in the host are all major contributors to its therapeutic advantages. Not only that, but L. reuteri treatment strengthens the host's defenses against infection and pro-inflammatory cytokine production while enhancing the growth and functionality of regulatory T cells. Numerous pediatric illnesses, particularly those pertaining to the intestinal health of infants, have been found to be well managed by L. reuteri, according to systematic reviews and meta-analyses. According to current research on L. reuteri, it may be useful in the management and avoidance of a number of common clinical disorders, including functional constipation, infantile colic, regurgitation, and diarrhea. Probiotic treatment for pediatric illnesses has had favorable benefits on bowel regularity in individuals with chronic constipation and has been found to successfully reduce screaming and/or fussing time in newborns with colic. Additionally, it quickens the emptying of the stomach and lessens distension. Several research have even come to the conclusion that this probiotic strain reduces the frequency of regurgitation. The potential of this probiotic strain for application in the treatment of several gastrointestinal disorders is evident from all of these findings. Therefore, this study aims to encapsulate and condense the advantages of this probiotic strain in clinical settings, with a particular emphasis on how it supports babies' and toddlers' immune systems and gut health.
芦特氏乳杆菌益生菌对预防幼儿期功能性胃肠功能紊乱的作用
事实证明,益生菌吕特氏乳杆菌可用于治疗多种胃肠道疾病。它能够分泌抗菌化合物,阻止病原微生物在宿主体内定植,并改变宿主体内共生微生物群的组成,这些都是其治疗优势的主要原因。不仅如此,L. reuteri 还能增强宿主对感染和促炎细胞因子产生的防御能力,同时提高调节性 T 细胞的生长和功能。根据系统综述和荟萃分析,许多儿科疾病,尤其是与婴儿肠道健康有关的疾病,都可以通过使用 L. reuteri 得到很好的控制。根据目前对 L. reuteri 的研究,它可能有助于治疗和避免一些常见的临床疾病,包括功能性便秘、婴儿肠绞痛、反胃和腹泻。益生菌治疗儿科疾病对慢性便秘患者的排便规律有好处,并能成功减少肠绞痛新生儿的尖叫和/或躁动时间。此外,它还能加快胃排空,减轻腹胀。一些研究甚至得出结论,这种益生菌株能减少反胃的频率。从所有这些研究结果来看,这种益生菌株在治疗多种胃肠道疾病方面的应用潜力是显而易见的。因此,本研究旨在总结和浓缩这种益生菌株在临床环境中的优势,特别强调它如何支持婴幼儿的免疫系统和肠道健康。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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