A safer method for disinfection of Bacillus Calmette-Guerin-containing urine: a prospective, randomized study.

Abstract

INTRODUCTION To examine whether disinfection of Bacillus Calmette-Guerin -containing urine with etaprocohol® (Ethanol 76.9-81.4 vol % and isopropanol as an additive) is safer than disinfection with sodium hypochlorite. METHOD In prospective research, safety, and efficacy was analyzed in five patients in the etaprocohol® disinfection group and five patients in the sodium hypochlorite disinfection group. The primary endpoint was the temperature change after disinfection and the secondary endpoint was the unpleasantness of the odor caused by disinfection. Additionally, concentration of gas produced was also examined. Sensory tests were taken from staff who performed urine disinfection and the odor generated by disinfection was evaluated. As a safety protocol, post-BCG-treated urine is cultured to verify the negative for Mycobacteria. RESULTS Mycobacteria was disinfected in all cases. The temperature rise following disinfection was significantly higher in the sodium hypochlorite group. The sensory test outcomes were significantly worse in the group disinfected with sodium hypochlorite. The concentration of gas generated immediately after disinfection in both groups reached the maximum value and declined quickly. CONCLUSIONS Disinfection of Bacillus Calmette-Guerin -containing urine with etaprocohol® was safer than disinfection with sodium hypochlorite, and an equivalent disinfection effect was achieved.