Influence of autolyzed yeast on the health of immunologically immature calves

Katlin Zamarchi Primel, A. C. Abreu, Bianca Milla, S. N. Oliveira, Karoline Vintureli Feliciano, Meire Christina Seki, H. G. Bertagnon
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Abstract

Autolyzed yeast is a supplement option for calves due to its ability to stimulate the immune system and performance; however, there are few studies about the effect of different yeast derivatives. Autolyzed yeast is rich in immunomodulatory substances, such as mannan oligosaccharides and β-glucans. These substances enhance the innate and humoral immunity of calves, resulting in greater intestinal and respiratory health. Thus, the objective of the study was to evaluate whether supplementation with autolyzed yeast improves the health of calves, in the challenge of naturally acquired Eimeriosis and bovine respiratory disease (BRD). Twenty Holstein calves aged 15 days, which had already suckled colostrum, were studied for 36 days. At 15 days of life all animals had naturally acquired Eimeriosis. They were challenged with an intranasal BRD vaccine at 30 days of age. The Supplemented group (n=10) received autolyzed yeast (10 g animal -1 day -1), once a day in milk for 36 days, and the Control group (n=10) was not supplemented throughout the experiment. Blood neutrophil: lymphocyte ratio, oxidative metabolism of neutrophils (OM), serum immunoglobulins and haptoglobin, occurrence of diarrhea, BRD, and weight gain were measured. After vaccination, all animals increased the blood neutrophil: lymphocyte ratio, but only the control group showed a 20% reduction in OM three days after the vaccine. The supplement affected the immune response, preserving OM, increasing serum IgA levels by 10% (P=0.006), and reducing haptoglobin serum levels (P=0.05). In addition, the supplement attenuated diarrhea and BRD, which allowed for greater weekly weight gain (difference of 2 kg between treatments, P<0.05), concluding that the autolyzed yeast showed some evidence that it can increase the health of calves challenged with Eimeriosis and the BRD vaccine.
自溶酵母对免疫不成熟小牛健康的影响
自溶酵母能刺激免疫系统,提高犊牛的生产性能,因此是犊牛的一种补充剂;然而,有关不同酵母衍生物效果的研究却很少。自溶酵母富含免疫调节物质,如甘露寡糖和β-葡聚糖。这些物质能增强犊牛的先天免疫和体液免疫,从而提高肠道和呼吸系统的健康水平。因此,本研究的目的是评估在犊牛面临自然感染的埃默里病和牛呼吸道疾病(BRD)的挑战时,补充自溶酵母是否能改善犊牛的健康状况。对 20 头 15 天大的荷斯坦犊牛进行了为期 36 天的研究,这些犊牛已经吮吸过初乳。在出生 15 天时,所有动物都患有自然感染的埃默里病。它们在 30 日龄时接种了鼻内 BRD 疫苗。补充组(n=10)在36天内每天一次在牛奶中添加自溶酵母(10克/只-1天-1天),对照组(n=10)在整个实验期间不添加任何物质。对血液中性粒细胞:淋巴细胞比率、中性粒细胞的氧化代谢(OM)、血清免疫球蛋白和隐球蛋白、腹泻发生率、BRD和增重进行了测定。接种疫苗后,所有动物的血液中性粒细胞:淋巴细胞比率都有所增加,但只有对照组在接种疫苗三天后 OM 减少了 20%。补充剂影响了免疫反应,保护了 OM,使血清 IgA 水平提高了 10%(P=0.006),并降低了血红蛋白血清水平(P=0.05)。此外,补充剂还减轻了腹泻和BRD,从而提高了周增重(不同处理间的差异为2千克,P<0.05),最后得出结论:自溶酵母显示出一些证据,表明它可以提高感染艾美耳病和BRD疫苗的犊牛的健康水平。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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