Herpes simplex virus-1 herpetic meningoencephalitis in Adults: Three cases in Casablanca, Morocco

Q3 Medicine

Ethiopian Medical Journal Pub Date : 2024-04-15 DOI:10.4314/emj.v62i2.8

Kamena Mwana-yile Hassan, Hanane Badi, Houda Lahrichi, Ouiame El Fadel, L. Marih, Moustapha Sodqi, Abdellaoui Soussi, K. M. El Filali

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引用次数: 0

Abstract

Herpes simplex virus type 1 is the first cause of acute focal encephalitis with necrosis of the cerebral parenchyma in children and adults, with high morbidity. Herpes simplex virus type 2 is the main cause of herpetic meningitis in adults, with a good evolution. Herpetic meningoencephalitis is rarely caused by HSV-1. We report three observations of PCR-confirmed HSV-1 meningoencephalitis in cerebrospinal fluid in young immunocompetent adults aged 27, 53, and 58. They presented with a meningoencephalitis picture consisting of a meningeal syndrome and encephalic involvement. Lumbar puncture confirmed lymphocytic clear-fluid meningitis, with a median white blood cell count of 97, red blood cell count of 69, proteinorachia of 0.78, and glycorachia of 0.62. Cerebral magnetic resonance imaging is the gold-standard neuroimaging technique in the management of herpetic meningoencephalitis. Early initiation of acyclovir has contributed significantly to improved patient outcomes and prognosis. Herpetic meningoencephalitis is a diagnostic and therapeutic emergency, with a very poor functional prognosis, particularly in terms of complications.

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成人单纯疱疹病毒-1疱疹性脑膜脑炎：摩洛哥卡萨布兰卡的三个病例

单纯疱疹病毒 1 型是导致儿童和成人急性局灶性脑炎并伴有脑实质坏死的首要病因，发病率较高。单纯疱疹病毒 2 型是成人疱疹性脑膜炎的主要病因，病情发展良好。疱疹性脑膜脑炎很少由 HSV-1 引起。我们报告了在年龄分别为 27、53 和 58 岁的免疫功能健全的年轻成人中观察到的三例经 PCR 证实的 HSV-1 脑膜脑炎病例。他们的脑膜脑炎症状包括脑膜综合征和脑部受累。腰椎穿刺证实为淋巴细胞性清脑膜炎，白细胞计数中位数为 97，红细胞计数中位数为 69，蛋白尿为 0.78，糖尿为 0.62。脑磁共振成像是治疗疱疹性脑膜脑炎的金标准神经成像技术。尽早使用阿昔洛韦大大改善了患者的治疗效果和预后。疱疹性脑膜脑炎是一种诊断和治疗上的急症，其功能性预后极差，尤其是在并发症方面。

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来源期刊

Ethiopian Medical Journal Medicine-Medicine (all)

CiteScore

0.40

自引率

0.00%

发文量

期刊介绍： The Ethiopian Medical Journal (EMJ) is the official Journal of the Ethiopian Medical Association (EMA) and devoted to the advancement and dissemination of knowledge pertaining to the broad field of medicine in Ethiopia and other developing countries. Prospective contributors to the Journal should take note of the instructions of Manuscript preparation and submission to EMJ as outlined below.