An Exploratory Assessment of Pre-Treatment Inflammatory Profiles in Gastric Cancer Patients.

Diseases Pub Date : 2024-04-16 DOI:10.3390/diseases12040078

C. V. I. Feier, Călin Muntean, Alaviana Monique Faur, Razvan Constantin Vonica, A. Blidari, Marius-Sorin Murariu, Sorin Olariu

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Abstract

Gastric cancer ranks as the fifth most common cancer, and the assessment of inflammatory biomarkers in these patients holds significant promise in predicting prognosis. Therefore, data from patients undergoing surgical intervention for gastric cancer over a 7-year period were analyzed. This study was retrospective and involved a preoperative investigation of six inflammatory parameters derived from complete blood counts. Statistical analysis revealed a significant increase in the leucocyte-to-monocyte ratio (LMR) (p = 0.048), along with a significant decrease in the number of lymphocytes and monocytes compared to patients with successful discharge. Taking into consideration patients undergoing emergency surgery, a significant increase in the LMR (p = 0.009), neutrophil-to-lymphocyte ratio (NLR) (p = 0.004), Aggregate Index of Systemic Inflammation (AISI) (p = 0.01), and Systemic Immune-Inflammation Index (SII) (p = 0.028) was observed. Regarding relapse, these patients exhibited significant increases in AISI (p = 0.032) and SII (p = 0.047). Inflammatory biomarkers represent a valuable tool in evaluating and predicting the prognosis of patients with gastric cancer.

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胃癌患者治疗前炎症特征的探索性评估

胃癌是第五大常见癌症，评估这些患者的炎症生物标志物对预测预后大有裨益。因此，我们对 7 年来接受胃癌手术治疗的患者数据进行了分析。该研究为回顾性研究，术前调查了从全血细胞计数中得出的六项炎症指标。统计分析显示，与成功出院的患者相比，白细胞与单核细胞比值（LMR）明显升高（p = 0.048），淋巴细胞和单核细胞数量明显减少。考虑到接受急诊手术的患者，观察到 LMR（p = 0.009）、中性粒细胞与淋巴细胞比值（NLR）（p = 0.004）、全身炎症综合指数（AISI）（p = 0.01）和全身免疫炎症指数（SII）（p = 0.028）显著增加。在复发方面，这些患者的 AISI（p = 0.032）和 SII（p = 0.047）显著增加。炎症生物标志物是评估和预测胃癌患者预后的重要工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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