Relationship between Neonatal Cerebral Fuels and Neurosensory Outcomes at 3 Years in Well Babies: Follow-Up of the Glucose in Well Babies (GLOW) Study.

Neonatology Pub Date : 2024-04-17 DOI:10.1159/000538377
Deborah L Harris, Philip J Weston, G. Gamble, Jane E Harding
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Abstract

INTRODUCTION We sought to investigate if the availability of cerebral fuels soon after birth in healthy term babies was associated with developmental progress at 3 years of age. METHODS Healthy term babies had plasma glucose, lactate, and beta-hydroxybutyrate concentrations measured over the first 5 days. At 3 years, parents completed Ages and Stages (ASQ-3) questionnaires between December 2018 and August 2022. Developmental progress, analysed using structural equation modelling, was compared between children whose median fuel concentrations were above and below the mean neonatal concentrations of glucose (3.3 mmol/L) and total ATP-equivalents (140 mmol/L) in the first 48 h and over the first 5 days. RESULTS Sixty-four (96%) families returned completed questionnaires. We found no differences between developmental progress in children who had median neonatal plasma glucose concentrations <3.3 or ≥3.3 mmol/L in the first 48 h (estimated mean difference in ASQ scores -1.0, 95% confidence interval: -5.8, 3.7, p = 0.66) or 120 h (-3.7, -12.0, 4.6, p = 0.39]). There were also no differences for any other measures of cerebral fuels including total ATP above and below the median over 48 and 120 h, any plasma or interstitial glucose concentration <2.6 mmol/L, or cumulative duration of interstitial glucose concentration <2.6 mmol/L. CONCLUSIONS There was no detectable relationship between plasma concentrations of glucose, lactate, and beta-hydroxybutyrate soon after birth in healthy term babies and developmental progress at 3 years of age.
健康婴儿 3 岁时新生儿脑燃料与神经感觉结果之间的关系:健康婴儿葡萄糖(GLOW)研究的后续研究。
导言我们试图研究健康足月儿出生后不久获得脑燃料是否与3岁时的发育进展有关。方法健康足月儿在出生后最初5天测量血浆葡萄糖、乳酸和β-羟基丁酸浓度。3岁时,父母在2018年12月至2022年8月期间填写了年龄与阶段(ASQ-3)问卷。使用结构方程模型分析,比较了在最初 48 小时和最初 5 天内燃料浓度中位数高于和低于新生儿葡萄糖(3.3 mmol/L)和总 ATP 当量(140 mmol/L)平均浓度的儿童的发育进展情况。我们发现,在最初 48 小时内,新生儿血浆葡萄糖浓度中位数<3.3 或≥3.3 mmol/L(ASQ 评分的估计平均差异为-1.0,95% 置信区间:-5.8,3.7,p = 0.66)或 120 小时内(-3.7,-12.0,4.6,p = 0.39]),儿童的发育进展没有差异。结论健康足月儿出生后不久的血浆葡萄糖、乳酸和β-羟丁酸浓度与3岁时的发育进展之间没有可检测到的关系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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