THE ROLE OF EXOSOMES IN THE DIAGNOSIS AND TREATMENT OF IMMUNE MEDIATED DERMATOSIS, TREATMENT OF SKIN WOUNDS AND ALOPECIA

Abstract

Hair loss, cicatricial skin changes and chronic immune-mediated dermatoses are a serious social and medical problem, as they can lead to social maladjustment of a person due to changes in appearance, constant pain and itching. At the same time, the existing methods of their diagnosis and complex treatment need to be improved. This review discusses novel promising approaches to the diagnosis and treatment of chronic immune-mediated dermatosis, alopecia, and skin wounds based on exosomes, extracellular vesicles secreted by cells that have specificity and the ability to penetrate into other cells and transfer their contents represented by various regulatory molecules to them. The review collects available information on the origin and exosomes cargo, reveals their diagnostic potential, and provides information on the therapeutic potential of these stem cell-derived vesicles.