MicroRNA (miRNA) PROFILING IN PROSTATE CANCER CARCINOGENESIS: EXPLORATORY RESEARCH

Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Pub Date : 2024-04-20 DOI:10.32539/jkk.v11i2.377

Maria Ulfa, Krisna Murti

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Abstract

Future research will continue to be carried out in terms of looking for molecular markers involved in the early processes of carcinogenesis, metastasis and therapeutic targets in prostate cancer patients. MicroRNAs (miRNAs) are small noncoding RNAs that contribute to prostate cancer progression by controlling genes involved in the androgen receptor (AR) signaling pathway, ectopic expression of proteins involved in the cell cycle and apoptosis, epithelial-mesenchymal transition (EMT) and metastasis of cancer stem cells (CSCs). This study was an exploratory study, the aim was to assess miRNA expression in low histopathological grade prostate cancer compared with high histopathological grade prostate cancer. The novelty of this research is to assess the 25 most increased (up-regulated) and 25 lowest (down-regulated) miRNAs from 800 types of miRNA. Next, we will analyze the mechanisms and confirm the carcinogenesis of prostate cancer. The research results can be used for further research data, especially for targeted therapy in prostate cancer patients.

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前列腺癌癌变中的微 RNA (miRNA)谱分析：探索性研究

今后将继续开展研究，寻找前列腺癌患者癌变、转移和治疗靶点早期过程中的分子标记物。微小RNA（miRNA）是一种小型非编码RNA，通过控制参与雄激素受体（AR）信号通路的基因、参与细胞周期和凋亡的蛋白质的异位表达、上皮-间质转化（EMT）以及癌症干细胞（CSCs）的转移来促进前列腺癌的发展。本研究是一项探索性研究，目的是评估低组织病理学分级前列腺癌与高组织病理学分级前列腺癌的 miRNA 表达情况。这项研究的新颖之处在于从 800 种 miRNA 中评估了 25 种增加（上调）最多的 miRNA 和 25 种减少（下调）最少的 miRNA。接下来，我们将分析前列腺癌的致癌机制并加以确认。研究成果可用于进一步的研究数据，尤其是前列腺癌患者的靶向治疗。

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Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya

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