Efficacy and safety of the combined drug (5% benzoyl peroxide + 1% clindamycin) in the treatment of acne: results of an open randomized comparative clinical study

Q4 Medicine

Vestnik dermatologii i venerologii Pub Date : 2024-04-24 DOI:10.25208/vdv16759

M. Rakhmatulina, I. N. Kondrakhina, Elena Petrovna Egorova, E. Novoselova, Georgy Traktirov

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引用次数: 0

Abstract

Background. Acne is one of the most common dermatoses, the presence of which significantly reduces the quality of life of patients. For patients with inflammatory, comedonal acne use of fixed combinations is a first-line therapy. Aims: to study the efficacy and safety of the Zerkalin Intensive (ZI) in the treatment of acne in comparison with the Effezel (EF). Methods: an open comparative study included 60 patients with acne: group 1 (n=30) received therapy with ZI, group 2 (n=30) with EF 1 time a day in the evening. The effectiveness of therapy was evaluated 2 weeks, 1, 2 and 3 months. Results: after 1 month of therapy, there was a significant improvement in 9 (30%) patients of the group 1 and in 9 (30%) patients of the group 2 (p=1,000), improvement – in 12 (40%) and 18 (60%) patients (p=0.106). After 2 months of using ZI and EF, complete resolution of rashes was observed in 11 (36.7%) and 6 (20%) (p=0.395), significant improvement in 13 (43.3%) and 11 (36.7%) (p=0.628), improvement in 6 (20%) and 13 (43.3%), respectively. After 3 months complete resolution of rashes was observed in 24 (80%) patients of the group 1 and in 12 (40%) patients of the group 2 (p=0.088), significant improvement in 5 (16.7%) and 11 (36.6%) patients (p=0.236), improvement in 1 (3.3%) and 7 (23.3%) patients, respectively. Against the background of the use of EF, 20 (66.7%) patients showed the appearance of slight dry skin and redness. No side effects were detected when using the ZI. Conclusions. A comparable high efficiency of ZI and EF in acne therapy has been established. Use of ZI made it possible to achieve the onset of a full clinical effect and a significant improvement in the clinical picture in a larger number of patients and in a shorter time.

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联合用药（5%过氧化苯甲酰+1%克林霉素）治疗痤疮的疗效和安全性：开放式随机比较临床研究的结果

背景。痤疮是最常见的皮肤病之一，它的出现大大降低了患者的生活质量。对于炎症性粉刺患者来说，使用固定复方制剂是一线治疗方法。目的：研究Zerkalin Intensive（ZI）与Effezel（EF）治疗痤疮的疗效和安全性比较。方法：对60名痤疮患者进行公开比较研究：第一组（30人）接受ZI治疗，第二组（30人）接受EF治疗，每天晚上1次。分别在 2 周、1 个月、2 个月和 3 个月后对疗效进行评估。结果：治疗 1 个月后，第 1 组的 9 名患者（30%）和第 2 组的 9 名患者（30%）的病情有了明显改善（P=1,000），12 名患者（40%）和 18 名患者（60%）的病情有了改善（P=0.106）。使用 ZI 和 EF 2 个月后，分别观察到 11（36.7%）和 6（20%）名患者的皮疹完全消退（p=0.395），13（43.3%）和 11（36.7%）名患者的皮疹明显好转（p=0.628），6（20%）和 13（43.3%）名患者的皮疹明显好转。3 个月后，观察到第一组 24 名（80%）和第二组 12 名（40%）患者的皮疹完全消退（P=0.088），分别有 5 名（16.7%）和 11 名（36.6%）患者的皮疹明显好转（P=0.236），1 名（3.3%）和 7 名（23.3%）患者的皮疹明显好转。在使用 EF 的背景下，20 名（66.7%）患者出现了轻微的皮肤干燥和发红现象。使用 ZI 时未发现任何副作用。结论ZI和EF治疗痤疮的高效性已得到证实。使用 ZI 可以使更多的患者在更短的时间内获得全面的临床疗效，并显著改善临床症状。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Vestnik dermatologii i venerologii

CiteScore

0.80

自引率

0.00%

发文量

审稿时长

8 weeks