Impact of theta transcranial alternating current stimulation on language production in adult classic galactosemia patients

IF 4.2 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Britt Derks, Varsha Shashi Kumar, Sai Yadnik, Bianca Panis, Annet M. Bosch, David Cassiman, Mirian C. H. Janssen, Teresa Schuhmann, M. Estela Rubio-Gozalbo, Bernadette M. Jansma
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Abstract

Patients with classic galactosemia (CG), an inborn error of galactose metabolism, suffer from impairments in cognition, including language processing. Potential causes are atypical brain oscillations. Recent electroencephalogram (EEG) showed differences in the P300 event-related-potential (ERP) and alterations in the alpha/theta-range during speech planning. This study investigated whether transcranial alternating current stimulation (tACS) at theta-frequency compared to sham can cause a normalization of the ERP post stimulation and improves language performance. Eleven CG patients and fourteen healthy controls participated in two tACS-sessions (theta 6.5 Hz/sham). They were engaged in an active language task, describing animated scenes at three moments, that is, pre/during/post stimulation. Pre and post stimulation, behavior (naming accuracy, voice-onset-times; VOT) and mean-amplitudes of ERP were compared, by means of a P300 time-window analysis and cluster-based-permutation testing during speech planning. The results showed that theta stimulation, not sham, significantly reduced naming error-percentage in patients, not in controls. Theta did not systematically speed up naming beyond a general learning effect, which was larger for the patients. The EEG analysis revealed a significant pre-post stimulation effect (P300/late positivity), in patients and during theta stimulation only. In conclusion, theta-tACS improved accuracy in language performance in CG patients compared to controls and altered the P300 and late positive ERP-amplitude, suggesting a lasting effect on neural oscillation and behavior.

Abstract Image

θ经颅交变电流刺激对典型半乳糖血症成人患者语言能力的影响。
典型半乳糖血症(CG)是一种先天性半乳糖代谢错误,患者的认知能力(包括语言处理能力)会受到影响。潜在的原因是大脑的非典型振荡。最近的脑电图(EEG)显示,在语言计划过程中,P300 事件相关电位(ERP)存在差异,α/θ 波段也有改变。本研究探讨了θ频率的经颅交变电流刺激(tACS)与假刺激相比,能否使刺激后的ERP恢复正常并改善语言表达能力。11 名 CG 患者和 14 名健康对照者参加了两次 tACS(θ 6.5 Hz/sham)治疗。他们参与了一项主动语言任务,在刺激前/刺激中/刺激后三个时刻描述动画场景。通过 P300 时间窗分析和基于聚类的言语计划期间permutation 测试,比较了刺激前和刺激后的行为(命名准确性、语音启动时间;VOT)和 ERP 的平均振幅。结果显示,θ刺激能显著降低患者的命名错误率,而不是假刺激。除了一般的学习效应外,θ 并没有系统地加快命名速度,而患者的学习效应更大。脑电图分析显示,仅在对患者进行θ刺激时,才会出现明显的刺激前后效应(P300/晚期阳性)。总之,与对照组相比,θ-tACS 提高了 CG 患者语言表达的准确性,并改变了 P300 和 ERP 晚期阳性振幅,这表明θ-tACS 对神经振荡和行为产生了持久的影响。
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来源期刊
Journal of Inherited Metabolic Disease
Journal of Inherited Metabolic Disease 医学-内分泌学与代谢
CiteScore
9.50
自引率
7.10%
发文量
117
审稿时长
4-8 weeks
期刊介绍: The Journal of Inherited Metabolic Disease (JIMD) is the official journal of the Society for the Study of Inborn Errors of Metabolism (SSIEM). By enhancing communication between workers in the field throughout the world, the JIMD aims to improve the management and understanding of inherited metabolic disorders. It publishes results of original research and new or important observations pertaining to any aspect of inherited metabolic disease in humans and higher animals. This includes clinical (medical, dental and veterinary), biochemical, genetic (including cytogenetic, molecular and population genetic), experimental (including cell biological), methodological, theoretical, epidemiological, ethical and counselling aspects. The JIMD also reviews important new developments or controversial issues relating to metabolic disorders and publishes reviews and short reports arising from the Society''s annual symposia. A distinction is made between peer-reviewed scientific material that is selected because of its significance for other professionals in the field and non-peer- reviewed material that aims to be important, controversial, interesting or entertaining (“Extras”).
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