Association between variation in hemoglobin A1c levels and diabetes therapy-related quality of life in patients with diabetes

IF 3.1 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Journal of Diabetes Investigation Pub Date : 2024-04-24 DOI:10.1111/jdi.14218

Dan Imai, Emi Ushigome, Ryosuke Sakai, Noriyuki Kitagawa, Masahide Hamaguchi, Masahiro Yamazaki, Michiaki Fukui

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引用次数: 0

Abstract

Aims/Introduction

We aimed to investigate the association between glycemic variability and quality of life (QOL) in patients with diabetes, which has not been studied previously.

Materials and Methods

Patients who were undergoing treatment at the Kyoto Prefectural University of Medicine Hospital and Kameoka City Hospital participated in the KAMOGAWA-DM study, and completed the diabetes therapy-related (DTR)-QOL questionnaire from January 2016 to July 2020 were included in this study. We used linear regression analyses to compare the association between DTR-QOL scores and glycemic variability.

Results

We included a total of 635 patients in this analysis. The hemoglobin A1c (HbA1c) levels of these patients were measured at least four times during the 9-month period, before and after answering the questionnaire. Results showed that HbA1c variability, HbA1c mean and duration of diabetes were negatively associated with the total DTR-QOL score. Conversely, the body mass index and total DTR-QOL score were positively associated with HbA1c variability.

Conclusions

A small variation in HbA1c level was associated with higher total DTR-QOL scores and the scores for each factor. Reducing blood glucose variability is significant when we treat diabetes.

查看原文本刊更多论文

糖尿病患者血红蛋白 A1c 水平变化与糖尿病治疗相关生活质量之间的关系。

材料与方法参与 KAMOGAWA-DM 研究并在 2016 年 1 月至 2020 年 7 月期间填写糖尿病治疗相关（DTR）-QOL 问卷的京都府立医科大学附属医院和龟冈市立医院接受治疗的患者被纳入本研究。我们使用线性回归分析比较了 DTR-QOL 评分与血糖变化之间的关联。这些患者的血红蛋白 A1c（HbA1c）水平在 9 个月的时间内至少测量了 4 次，分别在回答问卷前后进行。结果显示，HbA1c 变异性、HbA1c 平均值和糖尿病持续时间与 DTR-QOL 总分呈负相关。相反，体重指数和 DTR-QOL 总分与 HbA1c 变异性呈正相关。在治疗糖尿病时，降低血糖变异性意义重大。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Diabetes Investigation ENDOCRINOLOGY & METABOLISM-

CiteScore

6.50

自引率

9.40%

发文量

218

审稿时长

6-12 weeks

期刊介绍： Journal of Diabetes Investigation is your core diabetes journal from Asia; the official journal of the Asian Association for the Study of Diabetes (AASD). The journal publishes original research, country reports, commentaries, reviews, mini-reviews, case reports, letters, as well as editorials and news. Embracing clinical and experimental research in diabetes and related areas, the Journal of Diabetes Investigation includes aspects of prevention, treatment, as well as molecular aspects and pathophysiology. Translational research focused on the exchange of ideas between clinicians and researchers is also welcome. Journal of Diabetes Investigation is indexed by Science Citation Index Expanded (SCIE).