Neuroinflammation induced by amyloid-forming pancreatic amylin: Rationale for a mechanistic hypothesis

IF 3.3 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Noah S. Leibold, Florin Despa
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引用次数: 0

Abstract

Amylin is a systemic neuroendocrine hormone co-expressed and co-secreted with insulin by pancreatic β-cells. In persons with thype-2 diabetes, amylin forms pancreatic amyloid triggering inflammasome and interleukin-1β signaling and inducing β-cell apoptosis. Here, we summarize recent progress in understanding the potential link between amyloid-forming pancreatic amylin and Alzheimer's disease (AD). Clinical data describing amylin pathology in AD alongside mechanistic studies in animals are reviewed. Data from multiple research teams indicate higher amylin concentrations are associated with increased frequency of cognitive impairment and amylin co-aggregates with β-amyloid in AD-type dementia. Evidence from rodent models further suggests cerebrovascular amylin accumulation as a causative factor underlying neurological deficits. Analysis of relevant literature suggests that modulating the amylin-interleukin-1β pathway may provide an approach for counteracting neuroinflammation in AD.

Abstract Image

淀粉样蛋白形成的胰淀粉样蛋白诱发的神经炎症:机理假说的依据
淀粉样蛋白是一种全身性神经内分泌激素,与胰岛素一起由胰腺β细胞共同表达和分泌。在甲状腺 2 型糖尿病患者体内,淀粉样蛋白会形成胰腺淀粉样蛋白,引发炎性体和白细胞介素-1β 信号传导,诱导 β 细胞凋亡。在此,我们总结了了解淀粉样蛋白形成的胰腺淀粉样蛋白与阿尔茨海默病(AD)之间潜在联系的最新进展。我们回顾了描述 AD 中淀粉样蛋白病理的临床数据以及动物机理研究。来自多个研究小组的数据表明,淀粉样蛋白浓度越高,认知障碍的发生率就越高,而且淀粉样蛋白会与β-淀粉样蛋白共同聚集在AD型痴呆症中。来自啮齿类动物模型的证据进一步表明,脑血管淀粉样蛋白的积累是导致神经功能缺损的原因之一。对相关文献的分析表明,调节淀粉样蛋白-白介素-1β通路可能是对抗AD神经炎症的一种方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Biophysical chemistry
Biophysical chemistry 生物-生化与分子生物学
CiteScore
6.10
自引率
10.50%
发文量
121
审稿时长
20 days
期刊介绍: Biophysical Chemistry publishes original work and reviews in the areas of chemistry and physics directly impacting biological phenomena. Quantitative analysis of the properties of biological macromolecules, biologically active molecules, macromolecular assemblies and cell components in terms of kinetics, thermodynamics, spatio-temporal organization, NMR and X-ray structural biology, as well as single-molecule detection represent a major focus of the journal. Theoretical and computational treatments of biomacromolecular systems, macromolecular interactions, regulatory control and systems biology are also of interest to the journal.
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