Bonding-Free Capillary Microfluidics via a 3D-Printed Railed Microchannel

IF 1.9 4区 工程技术 Q2 Engineering
Wonhyung Lee, Hye Jin An, Da Bin Kim, Hojin Kim
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引用次数: 0

Abstract

Microfluidics is a promising research area that is widely used in biochemical applications. Recently, the commercialization of microfluidic devices composed of economical plastics has been highlighted. Plastic microfluidic devices must contain conformal contacts to construct a completely closed channel that prevents leakage during liquid transport. However, the conventional fabrication (i.e., injection molding and bonding) of plastic microfluidic devices requires empirical expertise, high cost, time-consuming, and complex procedures. This limits its extensive use in the research and development (R&D) phase to take the next steps toward final commercialization. In particular, iterative changes in the channel design typically lead to increased time and cost. This study proposes an easy-to-change and cost-effective fabrication method for 3D-printed microfluidic devices that offer bonding- and leakage-free spontaneous capillary flow (SCF). Locking pillar arrays on upper and lower substrates are simply and reliably assembled using friction forces. Incorporating inherent fabrication errors in 3D printing allows the intended and reproducible assembly gaps between the substrates to be used as microchannels. In addition, a novel side-opened (side-railed) channel geometry is applied to provide both SCF and virtual sidewalls (i.e., capillary barriers) along the microchannel. Finally, the proposed device demonstrates a potential fabrication method that can be utilized as a bridge between the R&D and commercialization phases.

Abstract Image

通过三维打印轨道微通道实现无粘接毛细管微流体技术
微流控技术是一个前景广阔的研究领域,在生化领域应用广泛。最近,由经济型塑料组成的微流体设备的商业化受到关注。塑料微流体设备必须包含保形接触,以构建一个完全封闭的通道,防止液体传输过程中发生泄漏。然而,塑料微流控装置的传统制造方法(即注射成型和粘接)需要经验丰富的专业技术,成本高、耗时长且程序复杂。这就限制了其在研发(R&D)阶段的广泛应用,使其无法向最终商业化迈出下一步。特别是,通道设计的反复更改通常会导致时间和成本的增加。本研究为三维打印微流体设备提出了一种易于更改且经济高效的制造方法,该方法可提供无粘合和无泄漏的自发毛细管流(SCF)。上下基底上的锁定支柱阵列可利用摩擦力简单可靠地组装起来。在三维打印中加入固有的制造误差,可将基底之间预定的、可重复的装配间隙用作微通道。此外,还采用了新颖的侧开(侧轨)通道几何形状,沿微通道提供 SCF 和虚拟侧壁(即毛细管屏障)。最后,所提出的设备展示了一种潜在的制造方法,可用作研发和商业化阶段之间的桥梁。
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来源期刊
CiteScore
4.10
自引率
10.50%
发文量
115
审稿时长
3-6 weeks
期刊介绍: The International Journal of Precision Engineering and Manufacturing accepts original contributions on all aspects of precision engineering and manufacturing. The journal specific focus areas include, but are not limited to: - Precision Machining Processes - Manufacturing Systems - Robotics and Automation - Machine Tools - Design and Materials - Biomechanical Engineering - Nano/Micro Technology - Rapid Prototyping and Manufacturing - Measurements and Control Surveys and reviews will also be planned in consultation with the Editorial Board.
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