Future perspectives of radiation therapy for Hodgkin Lymphoma: Risk-adapted, response-adapted, and safer than before

IF 3.3 4区 医学 Q2 HEMATOLOGY
Jessica Saddi, Amelia Barcellini, Manuel Gotti, Alessandro Mazzacane, Alessandra Tolva, Tanja Lazic, Luca Arcaini, Marco Zecca, Ester Orlandi, Andrea Riccardo Filippi
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引用次数: 0

Abstract

Classical Hodgkin lymphoma is a lymphoproliferative disease with a good prognosis mainly seen in young people. Nevertheless secondary malignancy, cardiac disease and infertility may affect the long survivors with significant impact on quality of life, morbidity and overall survival. In the last decades several treatment strategies were evaluated to reduce the toxicity of first line treatment such as avoiding radiotherapy or its reduction in terms of dosage and extension. Many trials including interim Positron Emission Tomography evaluation fail to compare efficacy between combined modality treatment versus chemotherapy alone in particular in early stage disease. In this review we analyze which subset of patients could take advantage from proton therapy in terms of toxicity and cost effectiveness.

Abstract Image

霍奇金淋巴瘤放射治疗的未来展望:适应风险、适应反应,比以前更安全
经典霍奇金淋巴瘤是一种淋巴增生性疾病,预后良好,主要见于年轻人。然而,继发性恶性肿瘤、心脏病和不育症可能会影响长期存活者的生活质量、发病率和总生存率。在过去的几十年中,人们评估了多种治疗策略,以减少一线治疗的毒性,如避免放疗或减少放疗剂量和延长放疗时间。包括正电子发射断层扫描中期评估在内的许多试验都未能比较联合治疗与单纯化疗的疗效,尤其是在早期疾病中。在这篇综述中,我们分析了哪些患者可以从质子治疗的毒性和成本效益方面获益。
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来源期刊
Hematological Oncology
Hematological Oncology 医学-血液学
CiteScore
4.20
自引率
6.10%
发文量
147
审稿时长
>12 weeks
期刊介绍: Hematological Oncology considers for publication articles dealing with experimental and clinical aspects of neoplastic diseases of the hemopoietic and lymphoid systems and relevant related matters. Translational studies applying basic science to clinical issues are particularly welcomed. Manuscripts dealing with the following areas are encouraged: -Clinical practice and management of hematological neoplasia, including: acute and chronic leukemias, malignant lymphomas, myeloproliferative disorders -Diagnostic investigations, including imaging and laboratory assays -Epidemiology, pathology and pathobiology of hematological neoplasia of hematological diseases -Therapeutic issues including Phase 1, 2 or 3 trials as well as allogeneic and autologous stem cell transplantation studies -Aspects of the cell biology, molecular biology, molecular genetics and cytogenetics of normal or diseased hematopoeisis and lymphopoiesis, including stem cells and cytokines and other regulatory systems. Concise, topical review material is welcomed, especially if it makes new concepts and ideas accessible to a wider community. Proposals for review material may be discussed with the Editor-in-Chief. Collections of case material and case reports will be considered only if they have broader scientific or clinical relevance.
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