Context matters: DNA virus infection reshapes DNA damage response pathways

IF 9 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cell Systems Pub Date : 2024-04-17 DOI:10.1016/j.cels.2024.03.008

Jeffrey R. Johnson

引用次数: 0

Abstract

The cellular DNA damage response pathway can have vastly different outcomes depending on the source of its activation. Justice and colleagues apply phosphoproteomics to uncover a divergence in DNA-PK and ATM kinase activities in the contexts of DNA damage and DNA virus infection.

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背景很重要：DNA病毒感染重塑DNA损伤应答途径

细胞 DNA 损伤反应途径会因激活源的不同而产生截然不同的结果。贾斯特及其同事应用磷蛋白组学发现了DNA-PK和ATM激酶在DNA损伤和DNA病毒感染情况下的活性差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Systems Medicine-Pathology and Forensic Medicine

CiteScore

16.50

自引率

1.10%

发文量

审稿时长

42 days

期刊介绍： In 2015, Cell Systems was founded as a platform within Cell Press to showcase innovative research in systems biology. Our primary goal is to investigate complex biological phenomena that cannot be simply explained by basic mathematical principles. While the physical sciences have long successfully tackled such challenges, we have discovered that our most impactful publications often employ quantitative, inference-based methodologies borrowed from the fields of physics, engineering, mathematics, and computer science. We are committed to providing a home for elegant research that addresses fundamental questions in systems biology.