Targeting methionine metabolism in cancer: opportunities and challenges

IF 13.9 1区医学 Q1 PHARMACOLOGY & PHARMACY

Trends in pharmacological sciences Pub Date : 2024-04-05 DOI:10.1016/j.tips.2024.03.002

Peng Bin, Chuanlong Wang, Hangchao Zhang, Yuqi Yan, Wenkai Ren

引用次数: 0

Abstract

Reprogramming of methionine metabolism is a conserved hallmark of tumorigenesis. Recent studies have revealed mechanisms regulating methionine metabolism within the tumor microenvironment (TME) that drive both cancer development and antitumor immunity evasion. In this review article we summarize advancements in our understanding of tumor regulation of methionine metabolism and therapies in development that target tumor methionine metabolism. We also delineate the challenges of methionine blockade therapies in cancer and discuss emerging strategies to address them.

查看原文本刊更多论文

以癌症中的蛋氨酸代谢为靶点：机遇与挑战

蛋氨酸代谢的重编程是肿瘤发生的一个共同特征。最近的研究揭示了肿瘤微环境（TME）中蛋氨酸代谢的调控机制，这种机制推动了癌症的发展和抗肿瘤免疫的逃避。在这篇综述文章中，我们总结了在了解肿瘤对蛋氨酸代谢的调控方面取得的进展，以及正在开发的针对肿瘤蛋氨酸代谢的疗法。我们还阐述了肿瘤蛋氨酸阻断疗法所面临的挑战，并讨论了应对这些挑战的新策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Trends in pharmacological sciences 医学-药学

CiteScore

23.90

自引率

0.70%

发文量

132

审稿时长

6-12 weeks

期刊介绍： Trends in Pharmacological Sciences (TIPS) is a monthly peer-reviewed reviews journal that focuses on a wide range of topics in pharmacology, pharmacy, pharmaceutics, and toxicology. Launched in 1979, TIPS publishes concise articles discussing the latest advancements in pharmacology and therapeutics research. The journal encourages submissions that align with its core themes while also being open to articles on the biopharma regulatory landscape, science policy and regulation, and bioethics. Each issue of TIPS provides a platform for experts to share their insights and perspectives on the most exciting developments in the field. Through rigorous peer review, the journal ensures the quality and reliability of published articles. Authors are invited to contribute articles that contribute to the understanding of pharmacology and its applications in various domains. Whether it's exploring innovative drug therapies or discussing the ethical considerations of pharmaceutical research, TIPS provides a valuable resource for researchers, practitioners, and policymakers in the pharmacological sciences.