Positioning risankizumab in the treatment algorithm of moderate-to-severe Crohn's disease

IF 2.7 4区医学 Q3 IMMUNOLOGY

Immunotherapy Pub Date : 2024-04-17 DOI:10.2217/imt-2023-0219

Francesca Lusetti, Ferdinando D'Amico, Mariangela Allocca, Federica Furfaro, Alessandra Zilli, Gionata Fiorino, Tommaso Lorenzo Parigi, Simona Radice, Laurent Peyrin-Biroulet, Silvio Danese

引用次数: 0

Abstract

Risankizumab is a humanized monoclonal antibody that inhibits the p19 subunit of IL-23 cytokine. Recently it has been approved for the treatment of patients with moderate-to-severe Crohn's disease (CD). We conducted a scoping review to summarize the available data on risankizumab and to define its positioning in the treatment algorithm of CD. Pubmed, Embase and Scopus databases were searched up to Oct 31, 2023 to identify studies reporting efficacy and safety data of risankizumab in patients with CD. Risankizumab is an effective and safe drug for the management of patients with moderate-to-severe CD. It could be used as first-line therapy in biologic-naive patients and in patients who have previously failed other biological therapies.

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利桑珠单抗在中重度克罗恩病治疗算法中的定位

利桑珠单抗是一种抑制 IL-23 细胞因子 p19 亚基的人源化单克隆抗体。最近，它被批准用于治疗中重度克罗恩病（CD）患者。我们进行了一次范围综述，总结了利桑珠单抗的现有数据，并确定了它在克罗恩病治疗算法中的定位。我们检索了截至2023年10月31日的Pubmed、Embase和Scopus数据库，以确定报告利坦珠单抗在CD患者中疗效和安全性数据的研究。利桑珠单抗是治疗中重度CD患者的一种有效、安全的药物。它可作为一线疗法用于对生物制剂无免疫反应的患者和曾接受过其他生物制剂治疗失败的患者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Immunotherapy 医学-免疫学

CiteScore

5.00

自引率

3.60%

发文量

113

审稿时长

6-12 weeks

期刊介绍： Many aspects of the immune system and mechanisms of immunomodulatory therapies remain to be elucidated in order to exploit fully the emerging opportunities. Those involved in the research and clinical applications of immunotherapy are challenged by the huge and intricate volumes of knowledge arising from this fast-evolving field. The journal Immunotherapy offers the scientific community an interdisciplinary forum, providing them with information on the most recent advances of various aspects of immunotherapies, in a concise format to aid navigation of this complex field. Immunotherapy delivers essential information in concise, at-a-glance article formats. Key advances in the field are reported and analyzed by international experts, providing an authoritative but accessible forum for this vitally important area of research. Unsolicited article proposals are welcomed and authors are required to comply fully with the journal''s Disclosure & Conflict of Interest Policy as well as major publishing guidelines, including ICMJE and GPP3.