Jianpi Gushen Huayu decoction ameliorated diabetic nephropathy through modulating metabolites in kidney, and inhibiting TLR4/NF-κB/NLRP3 and JNK/P38 pathways.

IF 4.2 3区医学 Q1 ENDOCRINOLOGY & METABOLISM

World Journal of Diabetes Pub Date : 2024-04-09 DOI:10.4239/wjd.v15.i3.502

Zi-Ang Ma, Li-Xin Wang, Hui Zhang, Han-Zhou Li, Li Dong, Qing-Hai Wang, Yuan-Song Wang, Bao-Chao Pan, Shu-Fang Zhang, Huan-Tian Cui, Shu-Quan Lv

引用次数: 0

Abstract

Jianpi Gushen Huayu Decoction (JPGS) has been used to clinically treat diabetic nephropathy (DN) for many years. However, the protective mechanism of JPGS in treating DN remains unclear.

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建皮固本化瘀汤通过调节肾脏代谢产物、抑制TLR4/NF-κB/NLRP3和JNK/P38通路，改善糖尿病肾病。

多年来，健皮固本化瘀汤（JPGS）一直被用于临床治疗糖尿病肾病（DN）。然而，JPGS 治疗糖尿病肾病的保护机制仍不清楚。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

World Journal of Diabetes ENDOCRINOLOGY & METABOLISM-

自引率

2.40%

发文量

909

期刊介绍： The WJD is a high-quality, peer reviewed, open-access journal. The primary task of WJD is to rapidly publish high-quality original articles, reviews, editorials, and case reports in the field of diabetes. In order to promote productive academic communication, the peer review process for the WJD is transparent; to this end, all published manuscripts are accompanied by the anonymized reviewers’ comments as well as the authors’ responses. The primary aims of the WJD are to improve diagnostic, therapeutic and preventive modalities and the skills of clinicians and to guide clinical practice in diabetes. Scope: Diabetes Complications, Experimental Diabetes Mellitus, Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus, Diabetes, Gestational, Diabetic Angiopathies, Diabetic Cardiomyopathies, Diabetic Coma, Diabetic Ketoacidosis, Diabetic Nephropathies, Diabetic Neuropathies, Donohue Syndrome, Fetal Macrosomia, and Prediabetic State.