Yikun Xing, Justin R. Clark, James D. Chang, Jacob J. Zulk, Dylan M. Chirman, Felipe-Andres Piedra, Ellen E. Vaughan, Haroldo J. Hernandez Santos, Kathryn A. Patras, Anthony W. Maresso
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引用次数: 0
Abstract
Extraintestinal pathogenic Escherichia coli (ExPEC) represents the most prevalent Gram-negative bacterial pathogen and is a primary
contributor to mortality due to antimicrobial resistance (AMR) globally (both deaths
attributable to and associated with AMR) (1, 2). ExPEC comprises the pathotypes of uropathogenic E. coli (UPEC), neonatal meningitis E. coli, and septicemia-associated isolates (3). ExPEC is the primary cause of bacteremia and urinary tract infections (UTIs) and
a frequent cause of neonatal meningitis (4, 5). In the United States, over 970,000 sepsis cases are admitted annually, with an
8.7% yearly increase in incidence among hospitalized patients, accounting for over
50% of hospital deaths (6, 7). Based on the Centers for Disease Control and Prevention (CDC) multiple cause-of-death
data (1999–2014), 6% of all deaths involved sepsis, 22% of these cases listing sepsis
as the underlying cause (8). Moreover, in 2017, approximately 48.9 million new cases of sepsis were recorded
globally, with 11 million sepsis-related deaths reported, accounting for 19.7% of
all worldwide deaths (9). In addition, sepsis management remains a major challenge for healthcare systems
worldwide, resulting in a disproportionately high burden in terms of cost and hospital
resource utilization. In the United States, sepsis management costs surpass those
for any other disease, exceeding $24 billion in 2013, representing 13% of total hospital
expenses and growing at three times the rate of other admissions (10). E. coli has emerged as the predominant causative agent of bloodstream infections (BSIs) in
both community and hospital settings over the past decade, accounting for 27.1% of
all bacteremia cases. Moreover, the incidence rate of E. coli bacteremia is estimated at 48 per 100,000 person-years, exhibiting a notable increase
with advancing age (11).
期刊介绍:
Infection and Immunity (IAI) provides new insights into the interactions between bacterial, fungal and parasitic pathogens and their hosts. Specific areas of interest include mechanisms of molecular pathogenesis, virulence factors, cellular microbiology, experimental models of infection, host resistance or susceptibility, and the generation of innate and adaptive immune responses. IAI also welcomes studies of the microbiome relating to host-pathogen interactions.