Development of a New Biocompatible Colloid System to Improve the Solubility of Celecoxib

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-04-10 DOI:10.1134/S1061933X23601270

Alireza Salabat, Nesa Ghorbani

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Abstract

In this research work, a new biocompatible microemulsion containing castor oil has been formulated to increase the solubility of celecoxib, as a well-known anti-inflammatory drug. In this formulation castor oil has also anti-inflammatory properties. The proposed oil-in-water microemulsion composed of Tween 80 as surfactant, isobutanol as co-surfactant, and castor oil as the oil phase. In the first step, the phase diagrams of the proposed colloid systems with surfactant to co-surfactant mass ratios of 4 : 1 and 2 : 1 were prepared at ambient temperature. Then, using the obtained phase diagrams, the appropriate formulations were selected by combining different percentages of water, oil, surfactant and co-surfactant in the microemulsion region. Some of physico-chemical properties, such as electrical conductivity, density, refractive index, surface tension and particle size of the selected microemulsion formulations have been determined at 298 K. After that, the solubility of celecoxib in the selected formulations was determined and compared with other reported microemulsion formulations. Interesting results from this section indicated that the solubility of celecoxib significantly increased compared to pure water and the previous proposed formulations. The results of this study can be used to provide suitable formulations based on the biocompatible microemulsions for celecoxib in pharmaceutical industry.

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开发新型生物相容性胶体系统以提高塞来昔布的溶解度

摘要在这项研究工作中，配制了一种含有蓖麻油的新型生物相容性微乳液，以增加塞来昔布（一种著名的消炎药）的溶解度。在这种配方中，蓖麻油还具有抗炎特性。拟议的水包油微乳剂由作为表面活性剂的吐温 80、作为辅助表面活性剂的异丁醇和作为油相的蓖麻油组成。首先，在常温下制备了表面活性剂与助表面活性剂质量比为 4 : 1 和 2 : 1 的拟议胶体系统的相图。然后，利用获得的相图，通过在微乳液区域组合不同比例的水、油、表面活性剂和助表面活性剂，选择合适的配方。然后，测定了塞来昔布在所选配方中的溶解度，并与其他已报道的微乳配方进行了比较。本部分得出的有趣结果表明，与纯水和之前提出的配方相比，塞来昔布的溶解度明显增加。这项研究的结果可用于为制药业提供基于塞来昔布生物相容性微乳剂的合适配方。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.