Nanoformulated herbal compounds: enhanced antibacterial efficacy of camphor and thymol-loaded nanogels

2区医学 Q1 Medicine

BMC Complementary and Alternative Medicine Pub Date : 2024-04-02 DOI:10.1186/s12906-024-04435-z

Abbas Abdollahi, Narges Fereydouni, Hamid Moradi, Abolfazl Karimivaselabadi, Elham Zarenezhad, Mahmoud Osanloo

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引用次数: 0

Abstract

Herbal components are highly useful assets for the advancement of novel antibacterial drugs. Nanotechnology holds great promise as an approach to enhance the effectiveness and develop the composition of these substances. The study developed nanogels incorporating camphor, thymol, and a combination derived from the initial nanoemulsions with particle sizes of 103, 85, and 135 nm, respectively. The viscosity of nanogels and the successful loading of compounds in them were examined by viscometery and ATR-FTIR studies. The bactericidal properties of the nanogels were examined against four bacterial strains. The nanogel containing camphor and thymol at 1250 µg/mL concentration exhibited complete growth suppression against Pseudomonas aeruginosa and Staphylococcus aureus. The thymol nanogel at 1250 µg/mL and the camphor nanogel at 2500 µg/mL exhibited complete inhibition of growth on Listeria monocytogenes and Escherichia coli, respectively. Both nanogels showed favorable effectiveness as antibacterial agents and could potentially examine a wide range of pathogens and in vivo studies.

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纳米配方草药化合物：增强樟脑和百里酚纳米凝胶的抗菌功效

草药成分是开发新型抗菌药物的非常有用的资产。纳米技术在提高这些物质的效力和开发其成分方面大有可为。这项研究开发出了纳米凝胶，其中含有樟脑、百里酚以及从最初的纳米乳液中提取的组合物，粒径分别为 103、85 和 135 纳米。粘度计和 ATR-FTIR 研究检测了纳米凝胶的粘度和化合物的成功负载情况。研究还考察了纳米凝胶对四种细菌菌株的杀菌性能。浓度为 1250 µg/mL 的樟脑和百里酚纳米凝胶完全抑制了铜绿假单胞菌和金黄色葡萄球菌的生长。浓度为 1250 µg/mL 的百里酚纳米凝胶和浓度为 2500 µg/mL 的樟脑纳米凝胶分别完全抑制了李斯特菌和大肠杆菌的生长。两种纳米凝胶都显示出良好的抗菌效果，可用于多种病原体和体内研究。

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来源期刊

BMC Complementary and Alternative Medicine INTEGRATIVE & COMPLEMENTARY MEDICINE-

CiteScore

7.00

自引率

0.00%

发文量

审稿时长

3 months

期刊介绍： BMC Complementary Medicine and Therapies is an open access journal publishing original peer-reviewed research articles on interventions and resources that complement or replace conventional therapies, with a specific emphasis on research that explores the biological mechanisms of action, as well as their efficacy, safety, costs, patterns of use and/or implementation.