{"title":"Partial Cell Reprogramming as a Way to Revitalize Living Systems","authors":"M. A. Shorokhova","doi":"10.1134/s1990519x23700104","DOIUrl":null,"url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Abstract</h3><p>Aging and associated diseases are acute problems of modern biology and medicine. Although aging cannot currently be prevented, its impact on the lifespan and health of older adults can potentially be minimized through interventions aimed at returning cells to normal function. The constant search for ways to rejuvenate and improve the regenerative capacity of cells led to the discovery in 2016 of a partial reprogramming method based on short-term expression of reprogramming factors (Oct4, Sox2, Klf4, and c-Myc). As a result, the youthful epigenetic signature of aging cells is restored. The effectiveness of the method is shown as in the system in vitro and in vivo. The presented review discusses the main successes of partial reprogramming, as well as the problems and unresolved questions that researchers have encountered. Data on molecular changes during the process of partial reprogramming are discussed separately. The partial reprogramming method provides a wide range of opportunities for fundamental research on aging and rejuvenation. Further work in this direction may lead to the development of therapeutic strategies to alleviate age-related diseases and, thus, improve health and longevity.</p>","PeriodicalId":9705,"journal":{"name":"Cell and Tissue Biology","volume":"38 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cell and Tissue Biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1134/s1990519x23700104","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Biochemistry, Genetics and Molecular Biology","Score":null,"Total":0}
引用次数: 0
Abstract
Aging and associated diseases are acute problems of modern biology and medicine. Although aging cannot currently be prevented, its impact on the lifespan and health of older adults can potentially be minimized through interventions aimed at returning cells to normal function. The constant search for ways to rejuvenate and improve the regenerative capacity of cells led to the discovery in 2016 of a partial reprogramming method based on short-term expression of reprogramming factors (Oct4, Sox2, Klf4, and c-Myc). As a result, the youthful epigenetic signature of aging cells is restored. The effectiveness of the method is shown as in the system in vitro and in vivo. The presented review discusses the main successes of partial reprogramming, as well as the problems and unresolved questions that researchers have encountered. Data on molecular changes during the process of partial reprogramming are discussed separately. The partial reprogramming method provides a wide range of opportunities for fundamental research on aging and rejuvenation. Further work in this direction may lead to the development of therapeutic strategies to alleviate age-related diseases and, thus, improve health and longevity.
期刊介绍：
The journal publishes papers on vast aspects of cell research, including morphology, biochemistry, biophysics, genetics, molecular biology, immunology. The journal accepts original experimental studies, theoretical articles suggesting novel principles and approaches, presentations of new hypotheses, reviews highlighting major developments in cell biology, discussions. The main objective of the journal is to provide a competent representation and integration of research made on cells (animal and plant cells, both in vivo and in cell culture) offering insight into the structure and functions of live cells as a whole. Characteristically, the journal publishes articles on biology of free-living and parasitic protists, which, unlike Metazoa, are eukaryotic organisms at the cellular level of organization.
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