The Intensity of Degradation and Synthesis of the Dermal Intercellular Matrix in Rats after Local Cold Injury against the Background of Metabolic Syndrome
N. A. Shutskiy, L. N. Gorbatova, S. L. Kashutin, N. S. Kholopov, L. L. Shagrov, A. L. Zashikhin
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引用次数: 0
Abstract
Research into the processes of tissue regeneration in the postcold period is currently in demand in connection with the development of the Arctic, which is characterized by extremely low temperatures. Metabolic or hormonal abnormalities based on insulin resistance and compensatory hyperinsulinemia, which can promote cardiovascular diseases and, consequently, lead to microcirculatory disorders, are aggravating factors that increase the consequences of cold injuries. In this work, we studied the processes of degradation and synthesis of the dermal intercellular matrix, as well as the concentration of sialic acids in the blood serum after local third-degree cold injury. It was revealed that the regenerative process after local cold damage began on the third day and was characterized by increased content of dermal collagen and thickness of collagen fibers. Regeneration against the background of metabolic syndrome was accompanied by a slowdown in tissue repair processes. The recovery process was accompanied with changed content of sialic acids in the blood serum. A distinctive feature of the dynamics of this indicator was enhanced concentration of sialic acids with metabolic disorders on the seventh day and a slow slight decrease throughout the experiment, which reached control values by the 21st day.
期刊介绍：
The journal publishes papers on vast aspects of cell research, including morphology, biochemistry, biophysics, genetics, molecular biology, immunology. The journal accepts original experimental studies, theoretical articles suggesting novel principles and approaches, presentations of new hypotheses, reviews highlighting major developments in cell biology, discussions. The main objective of the journal is to provide a competent representation and integration of research made on cells (animal and plant cells, both in vivo and in cell culture) offering insight into the structure and functions of live cells as a whole. Characteristically, the journal publishes articles on biology of free-living and parasitic protists, which, unlike Metazoa, are eukaryotic organisms at the cellular level of organization.
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