The Ethiopian Cognitive Assessment battery in Schizophrenia (ECAS): a validation study

IF 5.7 2区医学 Q1 PSYCHIATRY

NPJ Schizophrenia Pub Date : 2024-04-06 DOI:10.1038/s41537-024-00462-4

Yohannes Gebreegziabhere, Kassahun Habatmu, Matteo Cella, Atalay Alem

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Abstract

Cognitive impairment is common in people with schizophrenia (PWS). To detect the presence and its consequences, cognitive measures with sound psychometric properties are needed. However, these are lacking especially in low-income countries. Hence, we developed the Ethiopian Cognitive Assessment battery in Schizophrenia (ECAS). In this study, we evaluated the psychometric properties of the ECAS in a cross-sectional study involving 350 PWS. Confirmatory factor analysis demonstrated a one-factor solution. ECAS score correlated significantly but weakly with a disability measure (r = −0.13, p = 0.02) and symptom dimensions of PANSS (r between −0.12 and −0.29, p < 0.05), except for positive symptoms (r = −0.10, p > 0.05). Years of education (β = 0.12, 95% CI (0.09, 0.14), p < 0.001), male sex (β = 0.22, 95% CI (0.05, 0.39)), age β = −0.02, 95% CI (−0.03, −0.01), and medication side effects (β = −0.03, 95% CI (−0.06, −0.01), p = 0.021) were significantly associated with the composite score of ECAS. The Item Response Theory analysis showed that the tool best functions among participants with moderate cognitive impairment (difficulty coefficient between −1.12 and 0.27). The Differential Item Functioning analyses showed that education had a positive contribution on Digit Symbol Substitution Test (MH OR = 2.64, 95% CI (1.34, 5.20)). The results showed that ECAS is valid in assessing cognition in PWS in low-resource settings.

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埃塞俄比亚精神分裂症认知评估电池（ECAS）：验证研究

认知障碍在精神分裂症（PWS）患者中很常见。要检测是否存在认知障碍及其后果，需要具有良好心理测量特性的认知测量方法。然而，特别是在低收入国家，这些方法还很缺乏。因此，我们开发了埃塞俄比亚精神分裂症认知评估系统（ECAS）。在本研究中，我们在一项涉及 350 名精神病患者的横断面研究中评估了 ECAS 的心理测量特性。确认性因子分析显示了单因子解。ECAS得分与残疾测量（r = -0.13，p = 0.02）和PANSS症状维度（r介于-0.12和-0.29之间，p <0.05）有明显但微弱的相关性，但阳性症状除外（r = -0.10，p >0.05）。受教育年限（β = 0.12，95% CI (0.09，0.14)，p < 0.001）、男性（β = 0.22，95% CI (0.05，0.39)）、年龄（β = -0.02，95% CI (-0.03，-0.01)）和药物副作用（β = -0.03，95% CI (-0.06，-0.01)，p = 0.021）与 ECAS 的综合得分显著相关。项目反应理论分析表明，该工具在中度认知障碍参与者中的功能最佳（难度系数介于-1.12和0.27之间）。差异项目功能分析显示，教育程度对数字符号替换测试有积极影响（MH OR = 2.64，95% CI (1.34, 5.20)）。结果表明，在资源匮乏的环境中，ECAS对评估PWS患者的认知能力是有效的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

NPJ Schizophrenia Medicine-Psychiatry and Mental Health

CiteScore

6.30

自引率

0.00%

发文量

审稿时长

15 weeks

期刊介绍： npj Schizophrenia is an international, peer-reviewed journal that aims to publish high-quality original papers and review articles relevant to all aspects of schizophrenia and psychosis, from molecular and basic research through environmental or social research, to translational and treatment-related topics. npj Schizophrenia publishes papers on the broad psychosis spectrum including affective psychosis, bipolar disorder, the at-risk mental state, psychotic symptoms, and overlap between psychotic and other disorders.