{"title":"A facile microwave-mediated method of 1,4-dihydropyridine carboxylates synthesis by multicomponent reaction","authors":"Shravya Pachipulusu, Karuna Sree Merugu, Ramakrishna Rao Bhonsle, Aravind Kurnool","doi":"10.1002/jhet.4817","DOIUrl":null,"url":null,"abstract":"<p>An innovative green procedure has been devised to prepare derivatives of 1,4-dihydropyridine (1,4-DHP). This method works with a catalyst process using ethanol as solvent under microwave irradiation conditions, enabling swift reactions (<30 min) with impressive yields (90%–96%). It contributes to an environmentally friendly and easily executable process by using the energy efficiency method. Within 30 min, this method underscores ecologically conscious practices and offers simple purification, streamlining the process by omitting column chromatography. This method highlights the efficacy and eco-friendly nature of synthesizing 1,4-DHPs. This method combines four component reactions, utilizing EtOH as the solvent and triethylamine as the catalyst. Furthermore, the product was characterized by diverse spectroscopic analysis.</p>","PeriodicalId":194,"journal":{"name":"Journal of Heterocyclic Chemistry","volume":"61 6","pages":"1009-1014"},"PeriodicalIF":2.0000,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Heterocyclic Chemistry","FirstCategoryId":"92","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/jhet.4817","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
引用次数: 0
Abstract
An innovative green procedure has been devised to prepare derivatives of 1,4-dihydropyridine (1,4-DHP). This method works with a catalyst process using ethanol as solvent under microwave irradiation conditions, enabling swift reactions (<30 min) with impressive yields (90%–96%). It contributes to an environmentally friendly and easily executable process by using the energy efficiency method. Within 30 min, this method underscores ecologically conscious practices and offers simple purification, streamlining the process by omitting column chromatography. This method highlights the efficacy and eco-friendly nature of synthesizing 1,4-DHPs. This method combines four component reactions, utilizing EtOH as the solvent and triethylamine as the catalyst. Furthermore, the product was characterized by diverse spectroscopic analysis.
期刊介绍：
The Journal of Heterocyclic Chemistry is interested in publishing research on all aspects of heterocyclic chemistry, especially development and application of efficient synthetic methodologies and strategies for the synthesis of various heterocyclic compounds. In addition, Journal of Heterocyclic Chemistry promotes research in other areas that contribute to heterocyclic synthesis/application, such as synthesis design, reaction techniques, flow chemistry and continuous processing, multiphase catalysis, green chemistry, catalyst immobilization and recycling.
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