Fabrication of drug-loaded graded porous Ti6Al4V structures for load-bearing biomedical applications

IF 2.7 4区材料科学 Q3 MATERIALS SCIENCE, MULTIDISCIPLINARY

Journal of Materials Research Pub Date : 2024-04-10 DOI:10.1557/s43578-024-01335-3

Maninder Singh, Amoljit Singh Gill, Parneet Kaur Deol, Anupam Agrawal

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Abstract

The present study investigated drug-loaded, titanium alloy (Ti6Al4V) graded porous structure with desired mechanical properties for implant-based local drug delivery application. The fabricated graded porous metallic structures displayed compressive yield strength in a range of 110.8–283.8 MPa, open porosity 30.2–69.4% and Young’s modulus 2.2–12.1 GPa. These characteristics resemble the range for human bone tissue. The electrochemical corrosion behaviour of the fabricated structures was found satisfactory even though comparatively higher corrosion rate was observed in porous samples. The analysis showed the formation of protective passive layer on the exposed surface of the porous samples. The micrographs confirmed the presence of well-distributed interconnected pores in the peripheral region of the samples which were used to load drug (simvastatin) using different dispersion media. It was found that by varying the later, the in vitro release of loaded drug can be prolonged to as long as 14 days.

Graphical abstract

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制备用于承重生物医学应用的药物负载分级多孔 Ti6Al4V 结构

本研究调查了具有理想机械性能的药物负载钛合金（Ti6Al4V）分级多孔结构，用于植入式局部给药。制备的分级多孔金属结构的抗压屈服强度在 110.8-283.8 兆帕之间，开放孔隙率为 30.2-69.4%，杨氏模量为 2.2-12.1 GPa。这些特征与人体骨组织的范围相似。尽管多孔样品的腐蚀率相对较高，但所制造结构的电化学腐蚀行为令人满意。分析表明，多孔样品的暴露表面形成了被动保护层。显微照片证实，在使用不同分散介质装载药物（辛伐他汀）的样品外围区域存在分布均匀、相互连接的孔隙。研究发现，通过改变后一种分散介质，负载药物的体外释放时间可延长至 14 天。

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来源期刊

Journal of Materials Research 工程技术-材料科学：综合

CiteScore

4.50

自引率

3.70%

发文量

362

审稿时长

2.8 months

期刊介绍： Journal of Materials Research (JMR) publishes the latest advances about the creation of new materials and materials with novel functionalities, fundamental understanding of processes that control the response of materials, and development of materials with significant performance improvements relative to state of the art materials. JMR welcomes papers that highlight novel processing techniques, the application and development of new analytical tools, and interpretation of fundamental materials science to achieve enhanced materials properties and uses. Materials research papers in the following topical areas are welcome. • Novel materials discovery • Electronic, photonic and magnetic materials • Energy Conversion and storage materials • New thermal and structural materials • Soft materials • Biomaterials and related topics • Nanoscale science and technology • Advances in materials characterization methods and techniques • Computational materials science, modeling and theory