The role of TET2 in solid tumors and its therapeutic potential: a comprehensive review

Clinical and Translational Oncology Pub Date : 2024-04-10 DOI:10.1007/s12094-024-03478-5

Wenxin Da, Ziyu Song, Xiaodong Liu, Yahui Wang, Shengjun Wang, Jie Ma

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Abstract

Indeed, tumors are a significant health concern worldwide, and understanding the underlying mechanisms of tumor development is crucial for effective prevention and treatment. Epigenetics, which refers to changes in gene expression that are not caused by alterations in the DNA sequence itself, plays a critical role in the entire process of tumor development. It goes without saying that the effect of methylation on tumors is a significant aspect of epigenetics. Among the methylation modifications, DNA methylation is an important part, which plays a regulatory role in tumor-related genes. Ten-eleven translocation 2 (TET2) is a highly influential protein involved in the modification of DNA methylation. Its primary role is associated with the suppression of tumor development, making it a significant player in cancer research. However, TET2 is frequently mentioned in hematological diseases, its role in solid tumors has received little attention. Studying the changes of TET2 in solid tumors and the regulatory mechanism will facilitate its investigation as a clinical target for targeted therapy and may also provide directions for clinical treatment of malignant tumors.

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TET2 在实体瘤中的作用及其治疗潜力：全面综述

事实上，肿瘤是全球关注的重大健康问题，而了解肿瘤发生的内在机制对于有效预防和治疗肿瘤至关重要。表观遗传学（Epigenetics）是指并非由 DNA 序列本身的改变引起的基因表达变化，它在肿瘤发生发展的整个过程中起着至关重要的作用。毋庸置疑，甲基化对肿瘤的影响是表观遗传学的一个重要方面。在甲基化修饰中，DNA 甲基化是重要的一部分，它对肿瘤相关基因起着调控作用。十-十一易位 2（TET2）是一种参与 DNA 甲基化修饰的极具影响力的蛋白质。它的主要作用与抑制肿瘤发生有关，因此在癌症研究中占有重要地位。然而，TET2 在血液病中经常被提及，但它在实体瘤中的作用却很少受到关注。研究 TET2 在实体瘤中的变化及其调控机制，有助于将其作为靶向治疗的临床靶点进行研究，也可为恶性肿瘤的临床治疗提供方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Clinical and Translational Oncology

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