Kidney transplant in pediatric gut transplant recipients – Technical challenges and outcomes

IF 1.2 4区医学 Q3 PEDIATRICS

Pediatric Transplantation Pub Date : 2024-04-03 DOI:10.1111/petr.14744

Arpit Amin, Bishoy Emmanuel, Vikram Raghu, Ajai Khanna, Kyle Soltys, Rakesh Sindhi, Amit Tevar, Michael L. Moritz, Abhinav Humar, George Mazariegos, Armando Ganoza

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Abstract

BackgroundThere is limited data in the literature about pediatric kidney transplant (KT) following gut transplant (GT). The purpose of this study is to highlight the technical challenges and outcomes of KT in pediatric gut recipients who developed kidney failure (KF).MethodsA retrospective single‐center study of pediatric GT recipients from January 2000 to December 2019 was performed. In total, 14 (7%) out of 206 pediatric GT recipients developed KF and were listed for KT. Ten patients underwent kidney after gut transplant (KAGT), three patients underwent simultaneous kidney and re‐do gut transplant (SKAGT), and one patient died on the KT waitlist.Results1‐, 5‐, and 10‐year kidney graft survival was 100%, 91%, and 78%, respectively. 1‐, 5‐, and 10‐year GT graft survival was 100%, 77%, and 77%, respectively. 1‐, 5‐, and 10‐year patient survival was 100%, 91%, and 91%, respectively.ConclusionDespite the technical complexity, KAGT and SKAGT for pediatric GT recipients that develop KF can be performed with favorable outcomes.

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小儿肠道移植受者的肾移植--技术挑战和结果

背景关于肠道移植（GT）后小儿肾移植（KT）的文献数据有限。本研究旨在强调发生肾衰竭（KF）的小儿肠道受者进行 KT 的技术挑战和结果。方法对 2000 年 1 月至 2019 年 12 月期间的小儿 GT 受者进行回顾性单中心研究。在206例小儿GT受者中，共有14例（7%）出现KF并被列入KT名单。结果1年、5年和10年肾移植存活率分别为100%、91%和78%。肾移植1年、5年和10年存活率分别为100%、77%和77%。结论尽管技术复杂，但为发生 KF 的小儿 GT 受体进行 KAGT 和 SKAGT 仍能获得良好的结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric Transplantation 医学-小儿科

CiteScore

2.90

自引率

15.40%

发文量

216

审稿时长

3-8 weeks

期刊介绍： The aim of Pediatric Transplantation is to publish original articles of the highest quality on clinical experience and basic research in transplantation of tissues and solid organs in infants, children and adolescents. The journal seeks to disseminate the latest information widely to all individuals involved in kidney, liver, heart, lung, intestine and stem cell (bone-marrow) transplantation. In addition, the journal publishes focused reviews on topics relevant to pediatric transplantation as well as timely editorial comment on controversial issues.