Association of hair cortisol concentration with brain‐derived neurotrophic factor gene methylation: The role of sex as a moderator

Stress & Health Pub Date : 2024-04-06 DOI:10.1002/smi.3401

Zhenxu Li, Wanji Kong, Hye Yoon Park, Se Jun Koo, Minji Bang, Jung Tak Park, Eun Lee, Suk Kyoon An

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Abstract

Hair cortisol concentration (HCC) reflects the long‐term activity of the hypothalamus‐pituitary‐adrenal (HPA) axis in response to stress. Brain‐derived neurotrophic factor DNA methylation (BDNF DNAM) may affect HCC, and sex and Val66Met may contribute to this association. Thus, the aim of this study was to investigate the associations between HCC and Brain‐derived neurotrophic factor (BDNF) DNAM, and the moderating effects of Val66Met and sex. We recruited 191 healthy young participants (96 women, mean age 23.0 ± 2.6 years) and collected body samples to evaluate HCC, and to determine BDNF DNAM and Val66Met genotypes. We analyzed the effects of BDNF DNAM, sex, and Val66Met on HCC. We also evaluated the associations between BDNF DNAM and HCC in groups separated by sex and genotypes. We found a marked association of BDNF DNAM with HCC across men and women. After dividing the data by sex, a positive correlation of HCC with BDNF DNAM was found only in women. There was no substantial moderation effect of Val66Met genotypes on the association between BDNF DNAM and HCC. Therefore, BDNF DNAM was found to have positive association with HCC only in healthy young women, indicating that sex moderates the association of BDNF DNAM with long‐term HPA axis activity.

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毛发皮质醇浓度与脑源性神经营养因子基因甲基化的关系：性别的调节作用

毛发皮质醇浓度（HCC）反映了下丘脑-垂体-肾上腺（HPA）轴在应对压力时的长期活动。脑源性神经营养因子 DNA 甲基化（BDNF DNAM）可能会影响 HCC，而性别和 Val66Met 可能会促成这种关联。因此，本研究旨在调查 HCC 与脑源性神经营养因子 DNA 甲基化之间的关系，以及 Val66Met 和性别的调节作用。我们招募了 191 名健康的年轻参与者（96 名女性，平均年龄为 23.0 ± 2.6 岁），并采集了身体样本以评估 HCC，同时确定了 BDNF DNAM 和 Val66Met 基因型。我们分析了 BDNF DNAM、性别和 Val66Met 对 HCC 的影响。我们还评估了按性别和基因型分组的 BDNF DNAM 与 HCC 之间的关联。我们发现，在男性和女性中，BDNF DNAM 与 HCC 都有明显的关联。按性别划分数据后，发现只有女性的 HCC 与 BDNF DNAM 呈正相关。Val66Met 基因型对 BDNF DNAM 与 HCC 的关系没有实质性的调节作用。因此，BDNF DNAM仅在健康年轻女性中与HCC呈正相关，这表明性别调节了BDNF DNAM与HPA轴长期活动的关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Stress & Health

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