Deciphering the gastrointestinal carriage of Klebsiella pneumoniae

IF 2.9 3区医学 Q3 IMMUNOLOGY

Infection and Immunity Pub Date : 2024-04-10 DOI:10.1128/iai.00482-23

Andrew S. Bray, M. Ammar Zafar

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Abstract

Carl Friedländer’s identification of bacteria in the lungs of pneumonia patients in 1882 marked a pivotal moment, attributing the disease to bacterial causation, naming the bacterium Friedländer bacillus, which was subsequently named Klebsiella pneumoniae (K. pneumoniae) after microbiologist Edwin Klebs (1–3). In the ensuing 141 years, K. pneumoniae, a gram negative, encapsulated, non-motile, and rod-shaped bacterium, has been extensively studied as it can readily colonize human mucosal surfaces and is considered an opportunistic pathogen that can cause the development of pneumonia, bacteremia, pyogenic liver abscesses, and urinary tract infections (UTIs) (Fig. 1A) (4). What has been historically referred to as “Klebsiella pneumoniae” has since been demonstrated to be a complex of very closely related Klebsiella species (5–8), known as the K. pneumoniae species complex (KpSC), which comprises clinically relevant species that include K. pneumoniae, K. quasipneumoniae subsp. quasipneumoniae and similipneumoniae, K. variicola subsp. variicola and tropica, K. quasivariicola, and K. africana. This review will focus on K. pneumoniae sensu stricto, comprising ~85% of KpSC isolates (5, 9–12).

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解密肺炎克雷伯氏菌的胃肠道带菌情况

1882 年，卡尔-弗里德兰德（Carl Friedländer）在肺炎患者的肺部发现了细菌，这标志着一个关键时刻的到来，他将肺炎归因于细菌，并将这种细菌命名为弗里德兰德杆菌（Friedländer bacillus），随后又以微生物学家埃德温-克莱布斯（Edwin Klebs）的名字将其命名为肺炎克雷伯氏菌（Klebsiella pneumoniae，K. pneumoniae）(1-3)。在随后的 141 年中，肺炎克雷伯菌这种革兰氏阴性、包囊、无运动性、杆状的细菌受到了广泛的研究，因为它很容易在人体粘膜表面定植，被认为是一种机会性病原体，可导致肺炎、菌血症、化脓性肝脓肿和尿路感染（UTI）（图 1A）（4）。肺炎克雷伯氏菌在历史上一直被称为 "肺炎克雷伯氏菌"，后来被证实是由关系非常密切的克雷伯氏菌菌种组成的复合菌群（5-8），即肺炎克雷伯氏菌菌种复合体（KpSC），其中包括肺炎克雷伯氏菌、准肺炎克雷伯氏菌亚种和类肺炎克雷伯氏菌、变异肺炎克雷伯氏菌亚种和热带肺炎克雷伯氏菌、准变异肺炎克雷伯氏菌和非洲肺炎克雷伯氏菌等临床相关菌种。本综述将重点讨论占 KpSC 分离物约 85% 的严格意义上的肺炎双球菌（5, 9-12）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Infection and Immunity 医学-传染病学

CiteScore

6.00

自引率

6.50%

发文量

268

审稿时长

3 months

期刊介绍： Infection and Immunity (IAI) provides new insights into the interactions between bacterial, fungal and parasitic pathogens and their hosts. Specific areas of interest include mechanisms of molecular pathogenesis, virulence factors, cellular microbiology, experimental models of infection, host resistance or susceptibility, and the generation of innate and adaptive immune responses. IAI also welcomes studies of the microbiome relating to host-pathogen interactions.