Deciphering the gastrointestinal carriage of Klebsiella pneumoniae

IF 2.9 3区 医学 Q3 IMMUNOLOGY
Andrew S. Bray, M. Ammar Zafar
{"title":"Deciphering the gastrointestinal carriage of Klebsiella pneumoniae","authors":"Andrew S. Bray, M. Ammar Zafar","doi":"10.1128/iai.00482-23","DOIUrl":null,"url":null,"abstract":"Carl Friedländer’s identification of bacteria in the lungs of pneumonia patients in\n1882 marked a pivotal moment, attributing the disease to bacterial causation, naming\nthe bacterium Friedländer bacillus, which was subsequently named Klebsiella pneumoniae (K. pneumoniae) after microbiologist Edwin Klebs (1–3). In the ensuing 141 years, K. pneumoniae, a gram negative, encapsulated, non-motile, and rod-shaped bacterium, has been extensively\nstudied as it can readily colonize human mucosal surfaces and is considered an opportunistic\npathogen that can cause the development of pneumonia, bacteremia, pyogenic liver abscesses,\nand urinary tract infections (UTIs) (Fig. 1A) (4). What has been historically referred to as “Klebsiella pneumoniae” has since been demonstrated to be a complex of very closely related Klebsiella species (5–8), known as the K. pneumoniae species complex (KpSC), which comprises clinically relevant species that include K. pneumoniae, K. quasipneumoniae subsp. quasipneumoniae and similipneumoniae, K. variicola subsp. variicola and tropica, K. quasivariicola, and K. africana. This review will focus on K. pneumoniae sensu stricto, comprising ~85% of KpSC isolates (5, 9–12).","PeriodicalId":13541,"journal":{"name":"Infection and Immunity","volume":null,"pages":null},"PeriodicalIF":2.9000,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Infection and Immunity","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1128/iai.00482-23","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Carl Friedländer’s identification of bacteria in the lungs of pneumonia patients in 1882 marked a pivotal moment, attributing the disease to bacterial causation, naming the bacterium Friedländer bacillus, which was subsequently named Klebsiella pneumoniae (K. pneumoniae) after microbiologist Edwin Klebs (1–3). In the ensuing 141 years, K. pneumoniae, a gram negative, encapsulated, non-motile, and rod-shaped bacterium, has been extensively studied as it can readily colonize human mucosal surfaces and is considered an opportunistic pathogen that can cause the development of pneumonia, bacteremia, pyogenic liver abscesses, and urinary tract infections (UTIs) (Fig. 1A) (4). What has been historically referred to as “Klebsiella pneumoniae” has since been demonstrated to be a complex of very closely related Klebsiella species (5–8), known as the K. pneumoniae species complex (KpSC), which comprises clinically relevant species that include K. pneumoniae, K. quasipneumoniae subsp. quasipneumoniae and similipneumoniae, K. variicola subsp. variicola and tropica, K. quasivariicola, and K. africana. This review will focus on K. pneumoniae sensu stricto, comprising ~85% of KpSC isolates (5, 9–12).
解密肺炎克雷伯氏菌的胃肠道带菌情况
1882 年,卡尔-弗里德兰德(Carl Friedländer)在肺炎患者的肺部发现了细菌,这标志着一个关键时刻的到来,他将肺炎归因于细菌,并将这种细菌命名为弗里德兰德杆菌(Friedländer bacillus),随后又以微生物学家埃德温-克莱布斯(Edwin Klebs)的名字将其命名为肺炎克雷伯氏菌(Klebsiella pneumoniae,K. pneumoniae)(1-3)。在随后的 141 年中,肺炎克雷伯菌这种革兰氏阴性、包囊、无运动性、杆状的细菌受到了广泛的研究,因为它很容易在人体粘膜表面定植,被认为是一种机会性病原体,可导致肺炎、菌血症、化脓性肝脓肿和尿路感染(UTI)(图 1A)(4)。肺炎克雷伯氏菌在历史上一直被称为 "肺炎克雷伯氏菌",后来被证实是由关系非常密切的克雷伯氏菌菌种组成的复合菌群(5-8),即肺炎克雷伯氏菌菌种复合体(KpSC),其中包括肺炎克雷伯氏菌、准肺炎克雷伯氏菌亚种和类肺炎克雷伯氏菌、变异肺炎克雷伯氏菌亚种和热带肺炎克雷伯氏菌、准变异肺炎克雷伯氏菌和非洲肺炎克雷伯氏菌等临床相关菌种。本综述将重点讨论占 KpSC 分离物约 85% 的严格意义上的肺炎双球菌(5, 9-12)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Infection and Immunity
Infection and Immunity 医学-传染病学
CiteScore
6.00
自引率
6.50%
发文量
268
审稿时长
3 months
期刊介绍: Infection and Immunity (IAI) provides new insights into the interactions between bacterial, fungal and parasitic pathogens and their hosts. Specific areas of interest include mechanisms of molecular pathogenesis, virulence factors, cellular microbiology, experimental models of infection, host resistance or susceptibility, and the generation of innate and adaptive immune responses. IAI also welcomes studies of the microbiome relating to host-pathogen interactions.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信