An infant mouse model of influenza-driven nontypeable Haemophilus influenzae colonization and acute otitis media suitable for preclinical testing of novel therapies

IF 2.9 3区医学 Q3 IMMUNOLOGY

Infection and Immunity Pub Date : 2024-04-11 DOI:10.1128/iai.00453-23

Katherine R. Landwehr, Caitlyn M. Granland, Kelly M. Martinovich, Naomi M. Scott, Elke J. Seppanen, Luke Berry, Deborah Strickland, Alma Fulurija, Peter C. Richmond, Lea-Ann S. Kirkham

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Abstract

Nontypeable Haemophilus influenzae (NTHi) is a Gram-negative bacterium that exhibits opportunistic pathogenic behavior in humans (1). Asymptomatic nasopharyngeal colonization with NTHi is common and transient in children, with carriage frequencies ranging from ~15% to 100% depending upon age and geographic region (2–5). NTHi can also cause a range of diseases including sinusitis, conjunctivitis, pharyngitis, meningitis, bacteraemia, pneumonia, and otitis media (OM) (6, 7). Globally, NTHi is the predominant pathogen associated with chronic OM with effusion, recurrent acute OM, or acute OM with failure to treat (8). Early and dense NTHi colonization is associated with the development of acute and recurrent OM (6, 9–13). Triggers for the development of asymptomatic NTHi colonization into OM are thought to involve virus-induced inflammation, which permits proliferation and dissemination of NTHi from the nasopharynx along the Eustachian tube and into the middle ear (14, 15).

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适合对新型疗法进行临床前测试的流感驱动的非类型流感嗜血杆菌定植和急性中耳炎婴儿小鼠模型

非类型流感嗜血杆菌（NTHi）是一种革兰氏阴性细菌，对人类具有机会致病性（1）。无症状的鼻咽部 NTHi 定植在儿童中很常见，而且是一过性的，根据年龄和地理区域的不同，携带率从 ~15% 到 100% 不等（2-5）。NTHi 还可引起一系列疾病，包括鼻窦炎、结膜炎、咽炎、脑膜炎、菌血症、肺炎和中耳炎（OM）（6, 7）。在全球范围内，NTHi 是与慢性中耳炎伴流脓、复发性急性中耳炎或治疗无效的急性中耳炎相关的主要病原体（8）。早期密集的 NTHi 定植与急性和复发性 OM 的发生有关（6，9-13）。无症状的 NTHi 定植发展成 OM 的诱因被认为是病毒引起的炎症，炎症允许 NTHi 从鼻咽部沿着咽鼓管增殖和扩散到中耳（14，15）。

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来源期刊

Infection and Immunity 医学-传染病学

CiteScore

6.00

自引率

6.50%

发文量

268

审稿时长

3 months

期刊介绍： Infection and Immunity (IAI) provides new insights into the interactions between bacterial, fungal and parasitic pathogens and their hosts. Specific areas of interest include mechanisms of molecular pathogenesis, virulence factors, cellular microbiology, experimental models of infection, host resistance or susceptibility, and the generation of innate and adaptive immune responses. IAI also welcomes studies of the microbiome relating to host-pathogen interactions.