The Effect of Dalargin on the Level of Corticosterone in Rats with Different Individual Typological Features of Behavior in the PTSD Model

IF 0.5 4区 生物学 Q4 BIOLOGY
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引用次数: 0

Abstract

The effect of the synthetic analogue of leu-enkephalin (dalargin) on the level of corticosterone in the blood and the mass of the adrenal glands in rats with various typological features of behavior in the model of post-traumatic stress disorder (PTSD) was studied. Groups were formed: active low-anxiety (ALA) and high-anxiety (AHA), as well as passive low-anxiety (PLA) and high-anxiety (PHA) rats. Each of the four groups of rats was divided into three subgroups, where subgroup 1 is an intact control. Twenty days after the first stressful exposure, rats from subgroup 3 were injected intramuscularly with dalargin for seven days, and rats from subgroup 2 were injected with saline solution. It was found that the course of injections of dalargin into rats in the PTSD model had a positive effect on the studied indicators only in the group of active high-anxiety animals.

达拉金对创伤后应激障碍模型中具有不同个体行为类型特征的大鼠皮质酮水平的影响
摘要 研究了创伤后应激障碍(PTSD)模型中具有不同行为类型特征的大鼠体内白-脑啡肽合成类似物(达拉金)对血液中皮质酮水平和肾上腺质量的影响。实验分为四组:主动低焦虑(ALA)和高焦虑(AHA)大鼠,以及被动低焦虑(PLA)和高焦虑(PHA)大鼠。四组大鼠各分为三个亚组,其中亚组 1 为完整对照组。在第一次应激暴露 20 天后,向第 3 亚组大鼠肌肉注射达拉金,持续 7 天;向第 2 亚组大鼠注射生理盐水。研究发现,对创伤后应激障碍模型大鼠注射达拉金的疗程仅对活跃的高焦虑动物组的研究指标有积极影响。
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来源期刊
Biology Bulletin
Biology Bulletin 生物-生物学
CiteScore
0.70
自引率
20.00%
发文量
84
审稿时长
4-8 weeks
期刊介绍: Biology Bulletin (Izvestiya Rossiiskoi Akademii Nauk – Seriya Biologicheskaya) is an interdisciplinary journal of general biology. It focuses on fundamental studies in the fields of cell biology, biochemistry, zoology, botany, physiology, and ecology. This journal publishes current materials of experimental studies and surveys on current problems in general biology. It also publishes information on scientific conferences and new books in the fields of general biology.
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