Critical evaluation of the reliability of DNA methylation probes on the Illumina MethylationEPIC v1.0 BeadChip microarrays

IF 2.9 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Epigenetics Pub Date : 2024-04-02 DOI:10.1080/15592294.2024.2333660

Wei Zhang, Juan I. Young, Lissette Gomez, Michael A. Schmidt, David Lukacsovich, Achintya Varma, X. Steven Chen, Brian Kunkle, Eden R. Martin, Lily Wang

引用次数: 0

Abstract

DNA methylation (DNAm) plays a crucial role in a number of complex diseases. However, the reliability of DNAm levels measured using Illumina arrays varies across different probes. Previous research...

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对 Illumina MethylationEPIC v1.0 BeadChip 芯片上 DNA 甲基化探针可靠性的严格评估

DNA 甲基化（DNAm）在多种复杂疾病中起着至关重要的作用。然而，使用 Illumina 阵列测量的 DNAm 水平的可靠性因探针的不同而不同。以前的研究...

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来源期刊

Epigenetics 生物-生化与分子生物学

CiteScore

6.80

自引率

2.70%

发文量

审稿时长

3-8 weeks

期刊介绍： Epigenetics publishes peer-reviewed original research and review articles that provide an unprecedented forum where epigenetic mechanisms and their role in diverse biological processes can be revealed, shared, and discussed. Epigenetics research studies heritable changes in gene expression caused by mechanisms others than the modification of the DNA sequence. Epigenetics therefore plays critical roles in a variety of biological systems, diseases, and disciplines. Topics of interest include (but are not limited to): DNA methylation Nucleosome positioning and modification Gene silencing Imprinting Nuclear reprogramming Chromatin remodeling Non-coding RNA Non-histone chromosomal elements Dosage compensation Nuclear organization Epigenetic therapy and diagnostics Nutrition and environmental epigenetics Cancer epigenetics Neuroepigenetics