Iron indices and hemogram in renal anemia and the improvement with Tribulus terrestris green-formulated silver nanoparticles applied on rat model

IF 2.1 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Open Chemistry Pub Date : 2024-04-01 DOI:10.1515/chem-2023-0212

Xiujuan Wu, Jingyan Shi, Yangping Dai, Weiqi Tang, Huijun Cao, Jieyu Chen

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引用次数: 0

Abstract

The recent research was done to assess the hematological and biochemical disorders in nephrotoxicity induced by gentamicin (100 mg/kg) in Wistar rats. The green-formulated silver nanoparticles (AgNPs) by Tribulus terrestris leaf were analyzed by XRD, energy-dispersive X-ray spectrometer, and field emission scanning electron microscopy. The shape of the recent nanoparticles was spherical in size of 48 nm. In the in vivo, the classical and novel kidney injury parameters were used to assess the nephroprotective properties of AgNPs in animal model. Gentamicin decreased significantly (P ≤ 0.01) the value of PCV, concentration of HB, and count of RBC. The value of serum iron, erythropoietin, Cr, and urea raised in the gentamicin group. Leucogram revealed thrombocytopenia, granulocytosis, and leukocytosis. AgNPs improved the iron, erythropoietin, thrombocytes, leukogram, and erythrogram. The levels of creatinine, urea, GGT, ALT, AST, and ALP significantly reduced and albumin and total protein increased in group treated with AgNPs. Also, AgNPs significantly raised the anti-inflammatory cytokines, i.e., IL3, TGFβ, IL10, IL5, and IL4, and decreased the pro-inflammatory cytokines, i.e., TNFα, IL18, IL12, IL6, and IL1. These findings may offer AgNPs as a nephroprotective agent that could be a suitable therapeutic supplement in blood disorders conditions.

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肾性贫血中的铁指标和血象，以及在大鼠模型上应用绿刺蒺藜制剂银纳米粒子后的改善效果

最近的研究评估了庆大霉素（100 毫克/千克）诱导 Wistar 大鼠肾毒性时的血液和生化紊乱。用 XRD、能量色散 X 射线光谱仪和场发射扫描电子显微镜分析了刺蒺藜叶绿色配方银纳米粒子（AgNPs）。最近的纳米颗粒呈球形，大小为 48 nm。在动物模型中，利用经典和新型肾损伤参数评估了 AgNPs 的肾保护特性。庆大霉素能明显降低 PCV 值、HB 浓度和红细胞计数（P ≤ 0.01）。庆大霉素组的血清铁、促红细胞生成素、Cr和尿素值升高。白细胞图显示血小板减少、粒细胞和白细胞增多。AgNPs 可改善铁、促红细胞生成素、血小板、白细胞图和红细胞图。AgNPs 治疗组的肌酐、尿素、谷氨酰转肽酶、谷丙转氨酶、谷草转氨酶和谷草转氨酶水平明显下降，白蛋白和总蛋白水平上升。此外，AgNPs 还能明显提高抗炎细胞因子（即 IL3、TGFβ、IL10、IL5 和 IL4）的水平，降低促炎细胞因子（即 TNFα、IL18、IL12、IL6 和 IL1）的水平。这些发现可能会使 AgNPs 成为一种肾保护剂，成为血液疾病的一种合适的治疗补充剂。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Open Chemistry CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

3.80

自引率

4.30%

发文量

审稿时长

6 weeks

期刊介绍： Open Chemistry is a peer-reviewed, open access journal that publishes original research, reviews and short communications in the fields of chemistry in an ongoing way. The central goal is to provide a hub for researchers working across all subjects to present their discoveries, and to be a forum for the discussion of the important issues in the field. The journal is the premier source for cutting edge research in fundamental chemistry and it provides high quality peer review services for its authors across the world. Moreover, it allows for libraries everywhere to avoid subscribing to multiple local publications, and to receive instead all the necessary chemistry research from a single source available to the entire scientific community.