Can the ADO Index Be Used as a Predictor of Mortality from COVID-19 in Patients with COPD?

IF 2.8 3区医学 Q1 Medicine

International Journal of Chronic Obstructive Pulmonary Disease Pub Date : 2024-04-04 DOI:10.2147/copd.s440099

Esra Ertan Yazar, Gulsah Gunluoglu, Burcu Arpinar Yigitbas, Mukadder Calikoglu, Gazi Gulbas, Nilgün Yılmaz Demirci, Nurhan Sarioglu, Fulsen Bozkus, Nevin Taci Hoca, Nalan Ogan, Seda Tural Onur, Muzaffer Onur Turan, Filiz Kosar, Evrim Eylem Akpinar, Burak Mete, Can Ozturk

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引用次数: 0

Abstract

Background: Several studies have shown that the risk of mortality due to COVID-19 is high in patients with COPD. However, evidence on factors predicting mortality is limited.
Research Question: Are there any useful markers to predict mortality in COVID-19 patients with COPD?.
Study Design and Methods: A total of 689 patients were included in this study from the COPET study, a national multicenter observational study investigating COPD phenotypes consisting of patients who were followed up with a spirometry-confirmed COPD diagnosis. Patients were also retrospectively examined in terms of COVID-19 and their outcomes.
Results: Among the study patients, 105 were diagnosed with PCR-positive COVID-19, and 19 of them died. Body mass index (p= 0.01) and ADO (age, dyspnoea, airflow obstruction) index (p= 0.01) were higher, whereas predicted FEV₁ (p< 0.001) and eosinophil count (p= 0.003) were lower in patients who died of COVID-19. Each 0.755 unit increase in the ADO index increased the risk of death by 2.12 times, and each 0.007 unit increase in the eosinophil count decreased the risk of death by 1.007 times. The optimum cut-off ADO score of 3.5 was diagnostic with 94% sensitivity and 40% specificity in predicting mortality.
Interpretation: Our study suggested that the ADO index recorded in the stable period in patients with COPD makes a modest contribution to the prediction of mortality due to COVID-19. Further studies are needed to validate the use of the ADO index in estimating mortality in both COVID-19 and other viral respiratory infections in patients with COPD.

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ADO 指数能否作为 COPD 患者 COVID-19 死亡率的预测指标？

背景：多项研究表明，慢性阻塞性肺病患者因 COVID-19 导致死亡的风险很高。然而，有关预测死亡率因素的证据却很有限：研究设计与方法：COPET研究是一项调查慢性阻塞性肺病表型的全国性多中心观察性研究，由经肺活量测定确诊为慢性阻塞性肺病的随访患者组成。研究还对患者的 COVID-19 及其结果进行了回顾性研究：结果：在研究的患者中，105 人被确诊为 PCR 阳性 COVID-19，其中 19 人死亡。在 COVID-19 死亡患者中，体重指数（p= 0.01）和 ADO（年龄、呼吸困难、气流阻塞）指数（p= 0.01）较高，而预测 FEV1（p< 0.001）和嗜酸性粒细胞计数（p= 0.003）较低。ADO指数每增加0.755个单位，死亡风险就会增加2.12倍，而嗜酸性粒细胞计数每增加0.007个单位，死亡风险就会降低1.007倍。ADO指数的最佳临界值为3.5，其预测死亡率的敏感性为94%，特异性为40%：我们的研究表明，慢性阻塞性肺病患者在稳定期记录的ADO指数对预测COVID-19导致的死亡率有一定作用。还需要进一步的研究来验证 ADO 指数在估计 COVID-19 和其他慢性阻塞性肺病患者病毒性呼吸道感染死亡率中的应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Chronic Obstructive Pulmonary Disease RESPIRATORY SYSTEM-

CiteScore

5.10

自引率

10.70%

发文量

372

审稿时长

16 weeks

期刊介绍： An international, peer-reviewed journal of therapeutics and pharmacology focusing on concise rapid reporting of clinical studies and reviews in COPD. Special focus will be given to the pathophysiological processes underlying the disease, intervention programs, patient focused education, and self management protocols. This journal is directed at specialists and healthcare professionals

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