Nanofiber Scaffold-Based Tissue Engineering for the Treatment of Acute Liver Failure

IF 17.2 1区工程技术 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Advanced Fiber Materials Pub Date : 2024-04-02 DOI:10.1007/s42765-024-00395-8

Xiaojiao Liu, Xiang Yao, Qinjun OuYang, Ana L. Oliveira, Li Yan, Yaopeng Zhang

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引用次数: 0

Abstract

Acute liver failure (ALF) has a mortality rate of more than 40%. Currently, orthotopic liver transplantation is the sole clinical treatment for ALF, but its wide usage is severely limited due to donor shortage and immunological rejection. An emerging and promising technology for ALF treatment is liver tissue engineering (LTE), wherein porous scaffolds serve as a crucial component. Nanofiber scaffolds, which mimic the inherent structures of fibrous extracellular matrix well, provide an ideal environment for cell growth and tissue regeneration. Recently, several functional nanofiber scaffolds for LTE have been developed, which show impressive results in regulating cell function and repairing liver injury when combined with appropriate seeding cells and/or growth factors. This review firstly introduces the etiologies and treatment indicators of ALF. Subsequently, typical fabrication technologies of nanofiber scaffolds and their related applications for function regulation of liver-related cells and treatment of ALF are comprehensively summarized. Particular emphasis is placed on the strategies involving an appropriate combination of suitable seeding cells and growth factors. Finally, the current challenges and the future research and development prospects of nanofiber scaffold-based LTE are discussed. This review will serve as a valuable reference for designing and modifying novel nanofiber scaffolds, further promoting their potential application in LTE and other biomedical fields.

Graphical Abstract

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基于纳米纤维支架的组织工程学治疗急性肝衰竭

急性肝衰竭（ALF）的死亡率超过 40%。目前，正位肝移植是治疗 ALF 的唯一临床方法，但由于供体短缺和免疫排斥反应，其广泛应用受到严重限制。肝组织工程（LTE）是治疗 ALF 的一项新兴且前景广阔的技术，其中多孔支架是关键的组成部分。纳米纤维支架能很好地模拟纤维状细胞外基质的固有结构，为细胞生长和组织再生提供理想的环境。最近，几种用于LTE的功能性纳米纤维支架被开发出来，与适当的播种细胞和/或生长因子相结合，在调节细胞功能和修复肝损伤方面取得了令人瞩目的成果。本综述首先介绍了 ALF 的病因和治疗指标。随后，全面总结了纳米纤维支架的典型制造技术及其在肝脏相关细胞功能调节和 ALF 治疗中的相关应用。其中特别强调了适当组合合适的播种细胞和生长因子的策略。最后，讨论了基于纳米纤维支架的 LTE 目前面临的挑战和未来的研究与发展前景。这篇综述将为设计和改造新型纳米纤维支架提供有价值的参考，进一步促进其在LTE和其他生物医学领域的潜在应用。

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来源期刊

Advanced Fiber Materials Multiple-

CiteScore

18.70

自引率

11.20%

发文量

109

期刊介绍： Advanced Fiber Materials is a hybrid, peer-reviewed, international and interdisciplinary research journal which aims to publish the most important papers in fibers and fiber-related devices as well as their applications.Indexed by SCIE, EI, Scopus et al. Publishing on fiber or fiber-related materials, technology, engineering and application.