Total Synthesis of Moiramide B Using an Allylic Alkylation Approach

IF 1.7 4区化学 Q3 CHEMISTRY, ORGANIC

Synlett Pub Date : 2024-04-02 DOI:10.1055/s-0042-1751578

引用次数: 0

Abstract

An allylic side chain is introduced onto a chiral γ-amino-β-ketoamide by a Pd-catalyzed allylic alkylation. Subsequent ozonolysis and oxidation proceed only with Cbz-protected ketoamides. The total synthesis of moiramide B is finalized by peptide coupling.

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使用烯丙基烷基化方法全合成莫伊酰胺 B

通过钯催化的烯丙基烷基化反应，在手性 γ-氨基-β-酮酰胺上引入了烯丙基侧链。只有 Cbz 保护的酮酰胺才能进行后续的臭氧分解和氧化。最后通过肽偶联完成莫来酰胺 B 的全合成。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Synlett 化学-有机化学

CiteScore

3.40

自引率

5.00%

发文量

369

审稿时长

1 months

期刊介绍： SYNLETT is an international journal reporting research results and current trends in chemical synthesis in short personalized reviews and preliminary communications. It covers all fields of scientific endeavor that involve organic synthesis, including catalysis, organometallic, medicinal, biological, and photochemistry, but also related disciplines and offers the possibility to publish scientific primary data.