Polymeric microspheres redefining the landscape of colon-targeted delivery: A contemporary update

Abstract

During recent times, the delivery of the medications to the colon has seen more interest by the researchers, as it proved to be providing both options for treating local colon-related conditions and a route for systemic delivery of the various other types of medications. For these to happen, the medication has to provide protection from severe conditions in the stomach and small bowel, which either degrade the medication or may cause its premature release and uptake in the upper part of the digestive track. This review describes the various roles of microspheres as a colon-targeted drug delivery device (CTDDD). Through these review, we try to provide thorough information about the effects of the physiology of the colon. Also, we made an effort to highlight different mechanisms of colon targeting. Along with these, we have pointed out some of the important evaluation factors for carrying out a thorough investigation about the physicochemical and pharmaceutical properties of microspheres for targeting the colon. Also, we exchange views about the applications of microspheres as CTDDD in different diseases and disorders of the colon. Plus, we discuss the different challenges that occur during the formulation and targeting of these microspheres. At last, we share our thoughts on the possibilities in the near future in these domains, which will help in changing the scenario of how we can treat colon-related problems.